Advances in Biochips <p><a title="Registered Journal" href="" target="_blank" rel="noopener"><img class="journalreviewercredits" src="/journal/public/site/images/jasongong/Logo_ReviewerCredits-journal.jpg" alt="ReviewerCredits" align="right"></a><strong>Advances in Biochips (AB)</strong> (ISSN:2630-4511) is an open access, continuously published, international, refereed&nbsp; journal to show new ideas and optimize methods of this promising technology. With a broad range of disciplines and expanding topics, this journal encourages submissions of original research, review article, commentary, perspective, opinion, and so on.</p> <p>Topics of interest include, but are not limited to the following:<br>• Disease diagnosis<br>• Detection of bio agents<br>• DNA microarray<br>• Protein array<br>• Cell chip<br>• Tissue microarray<br>• Organ-on-a-chip<br>• Lab-on-a-chip<br>• Sequencing technology<br>• Chemical compound microarray<br>• Biosensor<br>• Microfluidics</p> en-US <p>Authors contributing to&nbsp;<em>Advances in Biochips</em>&nbsp;agree to publish their articles under the&nbsp;<a href="">Creative Commons Attribution-Noncommercial 4.0 International License</a>, allowing third parties to share their work (copy, distribute, transmit) and to adapt it, under the condition that the authors are given credit, that the work is not used for commercial purposes, and that in the event of reuse or distribution, the terms of this license are made clear.</p> (Snowy Wang) (Alan Tan) Mon, 16 May 2022 00:00:00 +0800 OJS 60 Simulation of gene regulatory elements for biosensing <p>Gene regulatory studies are of significant importance in many scenarios such as mental illness. 21% of U.S adults experience mental illnesses including 1 in 4 active-duty military personnel. Mental health can be identified in the body by different biomarkers. These biomarkers potentially controlled by riboswitches, which are located in mRNA and switch “ON” or “OFF” depending on the concentration of a biomarker. In this research, a known riboswitch reengineered and its response in the presence of a biomarker investigated. We changed computationally PreQ<sub>1</sub>, a known riboswitch that has the smallest aptamer, and then experimentally tested against biomarkers, dehydroepiandrosterone-sulfate (DHEA-S), Serotonin, Cortisol, Dopamine, Epinephrine, and Norepinephrine. A total of 7 variant riboswitches were tested in this research, 4 created computationally discussed here and 3 experimentally not covered in this paper. The results from these variants showed that variants 1 and 2 had different responses to DHEA-S then the expected PreQ<sub>1 </sub>response. A dose response showed downward trend as DHEA-S concentration increased. In conclusion of this research, riboswitches can be re-engineered to have a different response to biomarkers at the same time keeping the same structure.</p> Mallory Bates, Svetlana Harbough, Tarun Goswami ##submission.copyrightStatement## Mon, 16 May 2022 15:15:33 +0800 Cellulose based smart sensors <p><span class="s4"><span class="bumpedFont15">Cellulose fibres, cellulose nanofibers, cellulose nanocrystals and cellulose derivatives are all examples of cellulose-based materials</span></span><span class="s4"><span class="bumpedFont15">that </span></span><span class="s4"><span class="bumpedFont15">display superior characteristics</span></span> <span class="s4"><span class="bumpedFont15">with a number of desirable properties, including </span></span><span class="s4"><span class="bumpedFont15">biodegradability</span></span><span class="s4"><span class="bumpedFont15">, </span></span><span class="s4"><span class="bumpedFont15">sustainability, biocompatibility,</span></span> <span class="s4"><span class="bumpedFont15">thermal properties</span></span><span class="s4"><span class="bumpedFont15"> , optical transparency, flexibility, high mechanical strength,</span></span> <span class="s4"><span class="bumpedFont15">high porosity</span></span><span class="s4"><span class="bumpedFont15">,</span></span><span class="s4"><span class="bumpedFont15">hydrophilicity, </span></span><span class="s4"><span class="bumpedFont15">a large surface area</span></span> <span class="s4"><span class="bumpedFont15">and </span></span><span class="s4"><span class="bumpedFont15">broad chemical modification capabilities. </span></span><span class="s4"><span class="bumpedFont15">"Smart" materials based on cellulose </span></span><span class="s4"><span class="bumpedFont15">created by t</span></span><span class="s4"><span class="bumpedFont15">he</span></span><span class="s4"><span class="bumpedFont15"> chemical changes and physical incorporation/blending techniques</span></span> <span class="s4"><span class="bumpedFont15">offer numerous advantages</span></span><span class="s4"><span class="bumpedFont15">, </span></span><span class="s4"><span class="bumpedFont15">most notably their intelligent responses to environmental stimuli</span></span><span class="s4"><span class="bumpedFont15">. </span></span><span class="s4"><span class="bumpedFont15">Conductive networks are formed in cellulose-based composite materials by combining or coating conductive materials with the cellulose components or by directly carbonising the cellulose materials. </span></span><span class="s4"><span class="bumpedFont15">N</span></span><span class="s4"><span class="bumpedFont15">umerous </span></span><span class="s4"><span class="bumpedFont15">nanopaper</span></span><span class="s4"><span class="bumpedFont15">-based optical sensing platforms </span></span><span class="s4"><span class="bumpedFont15">are explained </span></span><span class="s4"><span class="bumpedFont15">and how they can be tailored to exhibit plasmonic or photoluminescent features suitable for sensing applications using nanomaterials</span></span><span class="s4"><span class="bumpedFont15"> or as biomate</span></span><span class="s4"><span class="bumpedFont15">r</span></span><span class="s4"><span class="bumpedFont15">ials</span></span><span class="s4"><span class="bumpedFont15">. The responsiveness of these "smart" materials to pH, temperature, light, electricity, magnetic fields and mechanical forces, among other parameters, </span></span><span class="s4"><span class="bumpedFont15">is</span></span><span class="s4"><span class="bumpedFont15"> also reviewed, as were their applications as drug delivery systems, hydrogels, electronic active papers, sensors, shape memory materials, smart membranes,</span></span><em><span class="s4"><span class="bumpedFont15"> etc</span></span></em><span class="s4"><span class="bumpedFont15">.</span></span></p> Ekta Jagtiani ##submission.copyrightStatement## Tue, 28 Jun 2022 16:47:44 +0800