TY - JOUR AU - Aaron J. Franke AU - William Paul Skelton IV PY - 2019/05/16 Y2 - 2024/03/29 TI - Quinine induced thrombotic microangiopathy and thrombocytopenia: A teaching hospital's perspective JF - Advances in General Practice of Medicine JA - AGPM VL - 2 IS - 1 SE - Case Report DO - 10.25082/AGPM.2019.01.003 UR - https://www.syncsci.com/journal/AGPM/article/view/283 AB - Although quinine is an infrequently prescribed drug, with malaria treatment being its only FDA-approved indication, unwitting exposure via beverages (e.g., tonic water), over the counter herbal remedies and illegal recreation drugs still occur. We present a unique case of a female patient who denied any known prior history of quinine exposure, who after being prescribed quinine tablets for restless leg syndrome, developed an immune-related thrombotic microangiopathy with thrombocytopenia and subsequent multi-organ failure. It was later elucidated that her only known potential source of prior quinine exposure was a remote history of crack-cocaine use. The patient survived this rare and severe inflammatory response with recovery of renal function and was able to discontinue dialysis. ER -