Advances in General Practice of Medicine <p><a title="Registered Journal" href="" target="_blank" rel="noopener"><img src="/journal/public/site/images/jasongong/Logo_ReviewerCredits-journal.jpg" alt="" width="17%" align="right"></a><strong>Advances in General Practice of Medicine (ISSN:2529-8127)</strong> is an open access, continuously published, international, refereed&nbsp; journal to promote comprehensive, coordinated and continuing care for the community members. This journal encourages submissions of original research, review&nbsp;article, clinical case study, clinical trial, commentary, perspective, opinion in the field addressed.</p> <p>Topics of interest include, but are not limited to, the following:<br>&nbsp;--Medical education and training<br>&nbsp;--Medical management and evaluation<br>&nbsp;--Clinical research<br>&nbsp;--Health policy and guideline development<br>&nbsp;--Whole person care<br>&nbsp;--Health economics<br>&nbsp;--International experiences and evolutions<br>&nbsp;--Family doctor service model<br>&nbsp;--Diagnostic and therapeutic<br>&nbsp;--Basic medicine system<br>&nbsp;-Health information technologies</p> SyncSci Publishing Pte. Ltd., Singapore en-US Advances in General Practice of Medicine 2529-8127 <p>Authors contributing to&nbsp;<em>Advances in General Practice of Medicine</em>&nbsp;agree to publish their articles under the&nbsp;<a href="">Creative Commons Attribution-Noncommercial 4.0 International License</a>, allowing third parties to share their work (copy, distribute, transmit) and to adapt it, under the condition that the authors are given credit, that the work is not used for commercial purposes, and that in the event of reuse or distribution, the terms of this license are made clear.</p> Impact of Coronavirus disease 2019 on macroeconomics and overall development in the Democratic Republic of Congo Oscar N. Luboya Olivier Mukuku Léon N. Kabamba Augustin M. Mutombo Paul M. Mawaw ##submission.copyrightStatement## 2020-12-30 2020-12-30 3 1 26 27 10.25082/AGPM.2020.01.003 Cryptococcus neoformans meningitis in an immunocompetent adult: A case report <p>Neuromeningeal cryptococcosis (NMC) is relatively rare in immunocompetent subjects. We report a Congolese case of NMC diagnosed in an apparently immunocompetent subject. A 35-year-old woman was admitted for acute meningoencephalitis. The cerebrospinal fluid (CSF) examination revealed cytological and biochemical abnormalities and the presence of <em>Cryptococcus neoformans</em> on direct examination with India ink and in culture. The serum dosage of cryptococcal antigens was titrated at 1:32. HIV and syphilis antibodies were negative and the blood CD4 lymphocyte count was 610/mm<sup>3</sup>. The patient had no other immunosuppressive factors, in particular no hematologic abnormalities, no solid tumor, or malnutrition. She was unsuccessfully treated with fluconazole intraveinously, and died after 10 days of treatment. This observation reminds us that NMC can occur in subjects without apparent immunosuppressive factor with a misleading clinical presentation. It is a rare infection with a severe prognosis even in immunocompetent patients.</p> Georges Yumba Numbi Berthe Kamalo Mwad Olivier Mukuku Claude Mulumba Mwamba ##submission.copyrightStatement## 2020-11-18 2020-11-18 3 1 23 25 10.25082/AGPM.2020.01.002