TY - JOUR AU - Zsuzsanna Rozmer AU - Pál Perjési PY - 2020/08/14 Y2 - 2024/03/29 TI - (E)-2-Benzylidenecyclanones: Part XVI.† Study on the interaction of some (E)-2-benzylidenebenzosuberone derivatives with serum albumin by UV-Vis method, inhibitory effect on topoisomerase JF - Journal of Pharmaceutical and Biopharmaceutical Research JA - JPBR VL - 2 IS - 1 SE - Research Article DO - 10.25082/JPBR.2020.01.003 UR - https://www.syncsci.com/journal/JPBR/article/view/447 AB - Interaction of some cyclic chalcone analogs, (E)-2-(4-X-benzylidene)-1-benzosuberone derivatives with bovine serum albumin (BSA) and human serum albumin (HSA) has been investigated using UV-Vis spectroscopic methods. Recording the UV-Vis spectra of compounds in the presence of BSA or HSA indicated interaction of the molecules with the hydrophobic binding site(s) of the proteins. Investigated analogs have shown remarkable topo I and topo II inhibitory activity compared to camptothecin and etoposide, respectively, at 40 μM concentration. The observed interactions between the cyclic chalcone analogs and the cellular macromolecules might play a role in the previously detected cytotoxicity against several tumor cell lines. ER -