Open Access Peer-reviewed Commentary

Opportunities and challenges of multidisciplinary conversion therapy in advanced hepatocellular carcinoma

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The roadmap for conversion therapy
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Submitted   Jul 31, 2024
Published   Sep 11, 2024
Issue    Vol 6 (2024)
DOI   10.25082/CCR.2024.01.003

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Ju-Hang Chu
Department of General Surgery, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai 200072, China
Lu-Yao Huang
Department of General Surgery, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai 200072, China
Ya-Ru Wang
Department of General Surgery, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai 200072, China
Jun Li
Department of General Surgery, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai 200072, China
Ying-Yu Cui corresponding author
1. Department of Cell Biology, Tongji University School of Medicine, Shanghai 200331, China; 2. Institute of Medical Genetics, Tongji University School of Medicine, Shanghai 200331, China; 3. State Key Laboratory of Cardiology, Tongji University School of Medicine, Shanghai 200331, China
Ming-Ping Qian
1. Department of General Surgery, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai 200072, China; 2. Department of General Surgery, Shanghai Tenth People's Hospital Chongming Branch, Shanghai 202150, China

Abstract

Surgical resection is still the most important radical treatment for primary hepatocellular carcinoma (HCC), but at present, the resection rate of newly diagnosed patients with HCC is only 30%. The recurrence rate of newly diagnosed patients suitable for surgical resection within 5 years after surgery is as high as 40%~70%. Low initial resection rate and high postoperative recurrence rate are important reasons restricting the overall treatment effects of HCC in China. Under this background, effectively improving the resection rate of HCC and reducing the postoperative recurrence rate have become the key topics to improve the treatment effects of HCC. Some initially unresectable HCC patients may have access to surgery through conversion therapy. Conversion therapy, which mainly involves the combination of local, systemic, and multiple treatment strategies, offers hope for patients with advanced HCC. But there are still some patients who do not benefit from conversion therapy. So, how to improve the conversion success rate is still one of the challenges that clinicians need to solve.

Keywords
hepatocellular carcinoma, conversion therapy, multidisciplinary therapy

Article Details

Supporting Agencies
2023 Key R&D Projects of Tongji University (No. 150029607160-24323); Chongming District, Shanghai `Scientific and Technological Innovation Action Plan for Sustainable Development' (CKY2023-37).
How to Cite
Chu, J.-H., Huang, L.-Y., Wang, Y.-R., Li, J., Cui, Y.-Y., & Qian, M.-P. (2024). Opportunities and challenges of multidisciplinary conversion therapy in advanced hepatocellular carcinoma. Current Cancer Reports, 6(1), 225-229. https://doi.org/10.25082/CCR.2024.01.003
Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

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