Frontiers in Molecular Immunology  (FMI) (ISSN: 2630-5429) is an open access, peer-reviewed journal, covers both basic immunology research and clinical applications, and provides the latest information and advancements in the immunological response of the host, both in vitro and in vivo.

FMI will accept high-profile submissions including but not limited to:
--Molecular mechanisms of innate and adaptive immunity phenomena
--Molecular aspects of immune regulation
--Cell signalling and activation
--Cellular receptors and soluble mediators
--Immunogenomics, immunoproteomics and immunoglycomics
--Molecular (immuno) therapeutics
--Impact of molecular changes at the tissue level

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Frontiers in Molecular Immunology  (FMI) (ISSN: 2630-5429)  is indexed by Google Scholar, Baidu Scholar, CQVIP, CNKI, and being indexed by other authoritative academic databases is under application.

Vol 1 No 1 (2019)

Published: 2019-08-15

Abstract views: 427   PDF downloads: 179  

Page 3-12

SOCS1/2 controls NF-κB activity induced by HSP70 by degrading MyD88-adapter-like protein (Mal) in porcine macrophages

blankpage Yanhong Yong, Lianyun Wu, Minglong Ma, Biao Fang, Tianyue Yu, Junyu Li, Canying Hu, Rumin Jia, Xianghong Ju

Heat stress induces suppressor of cytokine signaling (SOCS) 1 and SOCS2 expression in the intestinal gut and disrupts inflammatory cytokine production in pigs. These changes may be important to the development of inflammatory bowel disease in heat-stressed pigs. However, the underlying mechanisms have not yet been completely elucidated. In the present study, we examined the roles of SOCS1 and SOCS2 in regulating the nuclear factor (NF)-κB pathway in CRL-2845 porcine macrophages. Ectopic expression of HSP70 significantly modulated NF-κB activity (p ≤ 0.05). Moreover, co-expression of SOCS1 or SOCS2 with HSP70 reduced NF-κB activity, which was abolished by SOCS1 or SOCS2 knockdown with  small interfering RNA. Additionally, myeloid differentiation factor 88 (MyD88)-adaptor-like (Mal) protein was down-regulated in cells expressing SOCS1 and SOCS2. SOCS1 and SOCS2 were found to negatively regulate the activity of NF-κB induced by HSP70 overexpression by degrading Mal. These findings may facilitate the development of novel SOCS1-based and SOCS2-based therapeutic strategies for controlling heat stress-related disorders in pigs.

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Chenghua Li-photo  ISSN:  2630-5429
 Editor-in-Chief: Prof. Chenghua Li(China)
 Publishing Frequency: Bi-annual
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