Frontiers in Molecular Immunology  (FMI) (ISSN: 2630-5429) is an open access, peer-reviewed journal, covers both basic immunology research and clinical applications, and provides the latest information and advancements in the immunological response of the host, both in vitro and in vivo.

FMI will accept high-profile submissions including but not limited to:
--Molecular mechanisms of innate and adaptive immunity phenomena
--Molecular aspects of immune regulation
--Cell signalling and activation
--Cellular receptors and soluble mediators
--Immunogenomics, immunoproteomics and immunoglycomics
--Molecular (immuno) therapeutics
--Impact of molecular changes at the tissue level

Vol 2 No 1 (2021)

Published: 2021-03-16

Abstract views: 723   PDF downloads: 664  

Page 13-15

Efficacy and safety parameters of a novel COVID-19 vaccine

blankpage Bozena Riedel-Baima, Roman Zielinski, Kornelia Polok

Considering the fact that vaccine efficacy may be a difficult concept for physicians and health officials alike, we decided to explain it using data from the first publication on the efficacy and safety of a COVID-19 vaccine produced by Pfizer/BioNTech. We examined the published data and calculated common epidemiological parameters such as RRR (relative risk reduction), RR (relative risk), ARR (absolute risk reduction) and NNT (number needed to treat) for 3 groups of patients as described in the original paper. Further, we calculated safety parameters for the vaccine as NNH (number needed to harm) for any, related and severe side effects as mentioned by the investigators. We argue that both NNT and NNH are necessary estimates of how a vaccine might perform in real life and that a robust understanding of efficacy is vital for patients and health care providers as well as health officials in order to make responsible and balanced policy decisions regarding vaccination.

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Chenghua Li-photo  ISSN:  2630-5429
 Editor-in-Chief: Prof. Chenghua Li(China)
 Publishing Frequency: Bi-annual
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