Open Access Peer-reviewed Case Study

Targeted molecular therapy (modified RIST regimen) in relapsed high risk stage IV neuroblastoma: two cases report

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Paolo Indolfi, MD corresponding author
Selim Corbacioglu, MD
Silverio Perrotta, MD
Francesca Rossi, MD
Antonio Marte, MD
Elvira Pota, MD
Martina Di Martino, MD
Daniela Di Pinto, MD
Cristiana Indolfi, MD
Fiorina Casale, MD


The prognosis for children with recurrent or refractory neuroblastoma remains a significant clinical challenge, and currently there are no known curative salvage regimens. In this paper we investigated the effect of imatinib with rapamycin and the chemotherapeutic agents temozolomide and irinotecan. We treated two children with recurrent neuroblastoma with this so called RIST protocol. Both patients, off therapy for 15 and 31 months, respectively are well, and developing normally, without any complications. These findings suggest that a combination regimen of RIST may provide a therapeutic benefit with a favorable toxicity profile to a unfortunate subset of patients with neuroblastoma.

RIST therapy, neuroblastoma, pediatric cancer

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How to Cite
Indolfi, P., Corbacioglu, S., Perrotta, S., Rossi, F., Marte, A., Pota, E., Martino, M., Pinto, D., Indolfi, C., & Casale, F. (2018). Targeted molecular therapy (modified RIST regimen) in relapsed high risk stage IV neuroblastoma: two cases report. Theory and Clinical Practice in Pediatrics, 2(1), 29-31.


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