Theory and Clinical Practice in Pediatrics  (ISSN:2529-749X) is a broad ranging, international peer reviewed journal to pediatrics, publishing theoretical, clinical, and professional practice issues relevant to pediatrics, as broadly defined.

Topics of interest include, but are not limited to the following:
--Developmental-Behavioral Medicine  
--Pediatric allergy and immunology
--Pediatric cardiology
--Pediatric critical care
--Pediatric emergency medicine
--Pediatric endocrinology
--Pediatric gastroenterology
--Pediatric hematology
--Pediatric infectious disease
--Pediatric nephrology
--Pediatric neuropsychology
--Pediatric oncology
--Pediatric pulmonology

Indexed by Academic Databases


Theory and Clinical Practice in Pediatrics (TCPP) is indexed by Google Scholar, Baidu Scholar, CQVIP, CNKI, and being indexed by other authoritative academic databases is under application.

Vol 3 No 1 (2021)

Published: 2020-09-18

Abstract views: 183   PDF downloads: 49  

Page 63-70

Risk factors for neonatal sepsis in Lubumbashi, Democratic Republic of Congo: A retrospective case-control study

blankpage Adonis Muganza Nyenga, Olivier Mukuku, Janet Ziazia Sunguza, Amir N'simbo Assumani, Oscar Numbi Luboya, Stanislas Okitotsho Wembonyama

Purpose: Neonatal sepsis (NS) is a major cause of neonatal morbidity and mortality, particularly in developing countries. Delays in the identification and treatment of NS are the main contributors to the high mortality. This study aims to identify risk factors for NS in newborns in the two university hospitals in Lubumbashi, in the Democratic Republic of Congo. Methods: This hospital-based case-control study was carried out on 486 mother-newborn pairs using the systematic sampling method during November 2019 to October 2020. Data were analyzed using STATA software (version 15). Binary and multivariable logistic regression analyses were computed to identify the associated factors at 95% CI. Results: A total of 162 cases and 324 controls were included in this study. Multiple logistic regression analysis showed that the possible risk factors for NS in this study were low level of education (AOR = 9.16 [2.23-37.67]), maternal genitourinary tract infections (AOR = 42.59 [17.90-101.37]), premature rupture of membranes (AOR = 19.95 [7.27-54.76]), peripartum fever (AOR = 26.25 [2.31-297.83]), prolonged labor (AOR = 14.16 [3.88-51.71]), cesarean section (AOR = 3.57 [1.48-8.61]), obstructed vaginal delivery (AOR = 13.40 [1.32-136.19]), birth weight <1500 grams (AOR = 70.38 [8.64-572.95]), and between 1500-2500 grams (AOR = 7.90 [3.04-20.52]). Conclusion: The study found that maternal and neonatal factors were strongly associated with the risk of developing NS. The present study suggests the possibility of routine assessment of sepsis in newborns born with the above characteristics.

Abstract views: 520   PDF downloads: 220  

Page 52-56

Management of septic arthritis of the pediatric hip

blankpage Jessica L Hughes, Vidyadhar V Upasani, Andrew T Pennock, James D Bomar, Eric W Edmonds

Abstract: Purpose The purpose of this study was to compare outcomes and reoperation rate between open and arthroscopic treatment of a suspected isolated septic hip in the pediatric population. Methods Retrospective review was performed on two cohorts of pediatric patients who underwent surgical intervention for suspected isolated septic hip arthritis at a single institution. Patients were subdivided into two cohorts based on whether they underwent an open versus arthroscopic approach. Patients were excluded if they received an initial surgery from an outside institution, did not have an acute, active infection at presentation, defined as a hip aspiration leukocyte count <50,000 cells with <75% neutrophils, had extracaspular pathology or osteomyelitis, or had septic arthritis of a joint other than the hip. Results Fifty-six hips were included [Open group (n = 36); Arthroscopic group (n = 20)]. Six percent (2/36) of hips in the open group and 26% (5/19) of hips in the arthroscopy group had a positive tissue culture (p = 0.041). Eleven hips (31%) underwent postoperative immobilization in the open group compared to one hip (5%) in the arthroscopic group (p = 0.039). Conclusions In the setting of isolated arthritis, arthroscopy is a reasonable treatment modality with no observed additional risk compared to open arthrotomy. However, with concomitant osteomyelitis or soft tissue abscess, open arthrotomy should remain the mainstay approach to address all elements of the infection.
Level of Evidence: Level III

Abstract views: 667   PDF downloads: 233  

Page 57-62

Melioidosis and sickle cell disease: Description of a rare association

blankpage Mick Ya-Pongombo Shongo, Mimi Mujing Yav, Olivier Mukuku, Gaston Kankolongo, Kumel Kasongo Kumelundu, Aubin Ndjadi Wembonyama Kasongo, Augustin Mulangu Mutombo, André Kabamba Mutombo, Paulo Muntu Bunga, Léon Mwepu Tshilolo, Oscar Numbi Luboya, Stanis Okitotsho Wembonyama

Melioidosis and its germ are increasingly reported on the African continent and particularly in Central Africa, probably due to the increased awareness of clinicians and microbiologists and the growing recognition of the organism. It is called "Great Mimicker" because it produces a wide range of clinical characteristics such as would be found in patients living with sickle cell disease (SCD) in particular. However, to date, no publication presents this association between melioidosis and SCD. The authors describe here 3 clinical cases presenting this very rare association between melioidosis and SCD. These are 3 children with SCD (homozygous SS) residing in Lubumbashi in Haut-Katanga province in the Democratic Republic of Congo. One patient presented with sepsis as a clinical form of the disease. All 3 had presented a pulmonary form. Only one patient was treated specifically after the diagnosis of melioidosis; for the other two, this diagnosis was confirmed after their death. Thus the death rate is 66.67%. This article describes, through these 3 clinical cases, a very rare first association between melioidosis and SCD. This association requires research to establish whether, like Thalassemia, SCD can be considered a risk factor for melioidosis. A screening of cases of melioidosis in the general population should allow us to focus on this.

View All Issues

Tarro-photo  ISSN: 2529-749X
 Editor-in-Chief: Prof. Giullio Filippo Tarro (Italy)
 Publishing Frequency: Bi-annual
 Article Processing Charges (APC): Click   here   for more details
 Publishing Model: Open Access