Open Access Peer-reviewed Correspondence

Hematogone hyperplasia - A double edged sword

Article Sidebar

Histomicrographs
Download PDF
Submitted   Sep 24, 2020
Published   Nov 6, 2020
Issue    Vol 3 (2021)
DOI   10.25082/CCR.2021.01.001

Views

2968

Downloads

1683

Citations

PlumX Metrics

Main Article Content

Aditi Kundoo
Department of Haematology, Sir Ganga Ram Hospital, Rajinder Naga, New Delhi 110060, India
Sabina Langer corresponding author
Department of Haematology, Sir Ganga Ram Hospital, Rajinder Naga, New Delhi 110060, India
Divij Sachdeva
Department of Paediatric Hematoncology, Sir Ganga Ram Hospital, Rajinder Nagar, New Delhi 110060, India
Anupam Sachdeva
Department of Paediatric Hematoncology, Sir Ganga Ram Hospital, Rajinder Nagar, New Delhi 110060, India
Jyoti Kotwal
Department of Haematology, Sir Ganga Ram Hospital, Rajinder Naga, New Delhi 110060, India

Abstract

Hematogone hyperplasia is seen in many reactive and neoplastic conditions such as autoimmune cytopenia(s), post viral infections, Hodgkin/ Non Hodgkin lymphoma, acute myeloid leukaemia, post chemotherapy or stem cell transplant bone marrow. However, occasionally a marked reactive process like hematogone hyperplasia can mask an important underlying morphology. It is further compounded in cases where the diagnostic cells are few in number. Clinching a diagnosis in such cases becomes increasingly difficult.

Keywords
hematogone hyperplasia, flowcytometric, bone marrow biopsy

Article Details

How to Cite
Kundoo, A., Langer, S., Sachdeva, D., Sachdeva, A., & Kotwal, J. (2020). Hematogone hyperplasia - A double edged sword. Current Cancer Reports, 3(1), 64-67. https://doi.org/10.25082/CCR.2021.01.001
Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

References

  1. McKenna RW, Washington LT, Aquino DB, et al. Immunophenotypic analysis of hematogones (B-lymphocyte precursors) in 662 consecutive bone marrow specimens by 4-color flow cytometry. Blood, 2001, 98(8): 2498-2507. https://doi.org/10.1182/blood.V98.8.2498
  2. Chantepie SP, Cornet E, Sala¨un V, et al. Hematogones: an overview. Leukemia Research, 2013, 37(11): 1404-1411. https://doi.org/10.1016/j.leukres.2013.07.024
  3. Richard G, Brody J and Sun T. A case of acute megakaryocytic leukemia with hematogones. Leukemia, 1993, 7(11): 1900-1903.
  4. Anton-Harisi M, Douna V, Baka M, et al. Acute megakaryoblastic leukemia with increased hematogones in children. Journal of Pediatric Hematology/Oncology, 2012, 34(8): e337-e340. https://doi.org/10.1097/MPH.0b013e3182678ddb
  5. Chaudhari J, Borges A, Bansal S, et al. AML M7 Misdiagnosed as ALL. Indian Journal of Hematology and Blood Transfusion, 2014, 30(Suppl 1): 199-201. https://doi.org/10.1007/s12288-013-0326-4
  6. Rack KA, van den Berg E, Haferlach C, et al. European recommendations and quality assurance for cytogenomic analysis of haematological neoplasms. Leukemia, 2019, 33(8): 1851-1867. https://doi.org/10.1038/s41375-019-0378