Open Access

Peer-reviewed

Hypothesis

Main Article Content

Matti Pitkänen corresponding author
Reza Rastmanesh

Abstract

Telomeres are associated with the ends of DNA double strands. The lengths of the telomeres are controlled by the telomerase enzyme. The shortening of the telomeres is known to relate to aging. In cancers, telomere lengths are abnormally short. Telomeres could act as buffers shielding the part of DNA coding for the proteins. For cancer cells, germ cells and stem cells the length of the telomeres is not varying. There is an analogy with microtubules, which are highly dynamical and carry a longitudinal electric field, whose strength correlates with the microtubule length. Could sticky ends generate a longitudinal field along DNA double strand with strength determined by the lengths of the sticky ends? In the standard picture the flux of the longitudinal electric field would be proportional to the difference of the negative charges associated with the sticky ends. In TGD framework, DNA strands are accompanied by the dark analog of DNA with codons realized as 3-proton units at magnetic flux tubes parallel to DNA strands and neutralizing the negative charge of ordinary DNA except at the sticky ends. This allows considering the possibility that opposite sticky ends carry opposite charges generating a longitudinal electric field along the magnetic flux tube associated with the system. DNA/Telomere bioelectric field could serve as a novel bioelectric marker to be used for prognostic and diagnostic purposes in researches of cancer, aging, surgery grafts and rejuvenation. We propsed that DNA bioelectric field can be used as a futuristic bioelectric marker of cancer, aging and death.

Keywords
bioelectric marker, cancer, aging, rejuvenation, telomere, early disgnosis

Article Details

How to Cite
Pitkänen, Matti, and Reza Rastmanesh. 2021. “DNA Bioelectric Field: A Futuristic Bioelectric Marker of Cancer, Aging and Death - A Working Hypothesis”. Current Cancer Reports 3 (1), 68-80. https://doi.org/10.25082/CCR.2021.01.002.

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