Open Access Peer-reviewed Editorial

Tumor microenvironment

Main Article Content

Ping Wang corresponding author
tumor microenvironment

Article Details

Supporting Agencies
Tongji University
How to Cite
Wang, P. (2023). Tumor microenvironment. Current Cancer Reports, 5(1), 156-159.


  1. de Visser KE and Joyce JA. The evolving tumor microenvironment: From cancer initiation to metastatic outgrowth. Cancer Cell, 2023, 41(3): 374-403.
  2. Kroemer G, McQuade JL, Merad M, et al. Bodywide ecological interventions on cancer. Nature Medicine, 2023, 29: 59-74.
  3. Steele MM, Jaiswal A, Delclaux I, et al. T cell egress via lymphatic vessels is tuned by antigen encounter and limits tumor control. Nature Immunology, 2023, 24(4): 664-675.
  4. Cambier S, Gouwy M and Proost P. The chemokines CXCL8 and CXCL12: Molecular and functional properties, role in disease and efforts towards pharmacological intervention. Cellular & Molecular Immunology, 2023, 20(3): 217-251.
  5. Wu Q, Li B, Li Z, et al. Cancer-associated adipocytes: Key players in breast cancer progression. Journal of hematology & oncology, 2019, 12: 1-15.
  6. Grout JA, Sirven P, Leader AM, et al. Spatial positioning and matrix programs of cancer-associated fibroblasts promote T-cell exclusion in human lung tumors. Cancer Discovery, 2022, 12(11): 2606-2625.
  7. Krishnamurty AT, Shyer JA, Thai M, et al. LRRC15+ myofibroblasts dictate the stromal setpoint to suppress tumour immunity. Nature, 2022, 611(7934): 148-154.
  8. Vella G, Hua Y and Bergers G. High endothelial venules in cancer: Regulation, function, and therapeutic implication. Cancer Cell, 2023, 41(3): 527-545.
  9. Picoli CC, Goncalves BOP, Santos GSP, et al. Pericytes cross-talks within the tumor microenvironment. Biochimica et Biophysica Acta (BBA)-Reviews on Cancer, 2021, 1876(2): 188608.
  10. El-Kenawi A, Hänggi K and Ruffell B. The immune microenvironment and cancer metastasis. Cold Spring Harbor Perspectives in Medicine, 2020, 10(4): a037424.
  11. Liu Z, Gao Z, Li B, et al. Lipid-associated macrophages in the tumor-adipose microenvironment facilitate breast cancer progression. OncoImmunology, 2022, 11(1): 2085432.
  12. Li B, Liu S, Yang Q, et al. Macrophages in Tumor‐Associated Adipose Microenvironment Accelerate Tumor Progression. Advanced Biology, 2023, 7(1): 2200161.
  13. Wu Q, Zhang H, Sun S, et al. Extracellular vesicles and immunogenic stress in cancer. Cell Death & Disease, 2021, 12(10): 894.
  14. Wu Q, Yu X, Li J, et al. Metabolic regulation in the immune response to cancer. Cancer Communications, 2021, 41(8): 661-694.
  15. Li B, Sun S, Li J J, et al. Adipose tissue macrophages: implications for obesity-associated cancer. Military Medical Research, 2023, 10(1): 1-15.
  16. Fu A, Yao B, Dong T, et al. Emerging roles of intratumor microbiota in cancer metastasis. Trends in Cell Biology, 2022.
  17. Poore GD, Kopylova E, Zhu Q, et al. Microbiome analyses of blood and tissues suggest cancer diagnostic approach. Nature, 2020, 579(7800): 567-574.
  18. Sepich-Poore GD, Zitvogel L, Straussman R, et al. The microbiome and human cancer. Science, 2021, 371(6536): eabc4552.
  19. Jiang SS, Xie YL, Xiao XY, et al. Fusobacterium nucleatum-derived succinic acid induces tumor resistance to immunotherapy in colorectal cancer. Cell Host & Microbe, 2023, 31(5): 781-797.
  20. Tintelnot J, Xu Y, Lesker TR, et al. Microbiota-derived 3-IAA influences chemotherapy efficacy in pancreatic cancer. Nature, 2023, 615(7950): 168-174.
  21. Bender MJ, McPherson AC, Phelps CM, et al. Dietary tryptophan metabolite released by intratumoral Lactobacillus reuteri facilitates immune checkpoint inhibitor treatment. Cell, 2023, 186(9): 1846-1862.
  22. Liu SQ, Li B, Li JJ, et al. Neuroendocrine regulations in tissue-specific immunity: From mechanism to applications in tumor. Frontiers in Cell and Developmental Biology, 2022, 10: 896147.
  23. Venkatesh HS, Johung TB, Caretti V, et al. Neuronal activity promotes glioma growth through neuroligin-3 secretion. Cell, 2015, 161(4): 803-816.
  24. Zahalka AH and Frenette PS. Nerves in cancer. Nature Reviews Cancer, 2020, 20(3): 143-157.
  25. Deborde S, Gusain L, Powers A, et al. Reprogrammed Schwann cells organize into dynamic tracks that promote pancreatic cancer invasion. Cancer discovery, 2022, 12(10): 2454-2473.
  26. Wu LMN, Deng Y, Wang J, et al. Programming of Schwann cells by Lats1/2-TAZ/YAP signaling drives malignant peripheral nerve sheath tumorigenesis. Cancer Cell, 2018, 33(2): 292-308.
  27. Xu Y, Yan J, Tao Y, et al. Pituitary hormone $alpha$-MSH promotes tumor-induced myelopoiesis and immunosuppression. Science, 2022, 377(6610): 1085-1091.
  28. Liu SQ, Gao ZJ, Wu J, et al. Single-cell and spatially resolved analysis uncovers cell heterogeneity of breast cancer. Journal of Hematology & Oncology, 2022, 15(1): 19.
  29. Bejarano L, Jordāo MJC and Joyce JA. Therapeutic targeting of the tumor microenvironment. Cancer discovery, 2021, 11(4): 933-959.