Open Access Peer-reviewed Case Report

The Role of Radiotherapy in Familial, Multiple and Symptomatic Cerebral Cavernomas

Main Article Content

Yasemin Benderli Cihan corresponding author
Yusuf Türker
Şeyma Demir

Abstract

Stereotactic radiosurgery is an effective and safe method that can help prevent the development of deep-seated or large-sized cavernomas. However, there are limited studies on familial, multiple and symptomatic cerebral cavernous malformations (CCM).  The approach in these cases is not yet clear. This case is a CCM that can be confused with other brain masses and metastases, and contributes to the literature in terms of genetic transmission, management and treatment of cavernomas.

Keywords
cerebral cavernous malformation, radiotherapy, familial transmission

Article Details

How to Cite
Cihan, Y. B., Türker, Y., & Demir, Şeyma. (2025). The Role of Radiotherapy in Familial, Multiple and Symptomatic Cerebral Cavernomas. Current Cancer Reports, 7, 290-292. https://doi.org/10.25082/CCR.2025.01.005

References

  1. Dayawansa S, Dumot C, Mantziaris G, et al. Stereotactic radiosurgery (SRS) for patients with brainstem cerebral cavernous malformations (CCMs): an international, multicentric study. Scientific Reports. 2024, 14(1): 25933. https://doi.org/10.1038/s41598-024-77140-z
  2. Tos SM, Mantziaris G, Shaaban A, et al. Stereotactic radiosurgery for intracranial cavernous malformations of the deep-seated locations: systematic review and meta-analysis. Neurosurgical Review. 2024, 47(1): 186. https://doi.org/10.1007/s10143-024-02434-9
  3. Lu J, Li Z, Deng H, et al. Treatment Modalities and Outcomes in Brainstem Cavernous Malformations: A Large Multicenter Observational Cohort Study. Stroke. 2024, 55(5): 1151-1160. https://doi.org/10.1161/strokeaha.123.046203
  4. Eriksson M, Hayat R, Kinsella E, et al. Medical management and surgery versus medical management alone for symptomatic cerebral cavernous malformation (CARE): a feasibility study and randomised, open, pragmatic, pilot phase trial. The Lancet Neurology. 2024, 23(6): 565-576. https://doi.org/10.1016/s1474-4422(24)00096-6
  5. da Fontoura Galvão G, Verly G, Bessa MD, et al. Gamma Knife Stereotactic Radiosurgery for Cerebral Cavernous Malformations: Meta-Analysis of Reconstructed Time-to-Event Data. Cerebrovascular Diseases. 2025, 54(2): 196-207. https://doi.org/10.1159/000539079
  6. Dulamea AO, Lupescu IC. Cerebral cavernous malformations – An overview on genetics, clinical aspects and therapeutic strategies. Journal of the Neurological Sciences. 2024, 461: 123044. https://doi.org/10.1016/j.jns.2024.123044
  7. Myeong HS, Jeong SS, Kim JH, et al. Long-Term Outcomes of Gamma Knife Radiosurgery for Cerebral Cavernous Malformations: 10 Years and Beyond. Journal of Korean Medical Science. 2024, 39(32): e229. https://doi.org/10.3346/jkms.2024.39.e229
  8. Kim J, Byun J, Lee DH, et al. A Potential Risk of Radiation-Induced Cavernous Malformations Following Adjuvant Gamma Knife Radiosurgery for Mesial Temporal Lobe Epilepsy. Journal of Korean Neurosurgical Society. 2024, 67(4): 458-466. https://doi.org/10.3340/jkns.2023.0203
  9. Fotakopoulos G, Georgakopoulou V, Papalexis P, et al. Management of intracranial cavernous malformations using conservative vs. surgical and/or radiosurgical treatment: A systematic review and meta‑analysis. Experimental and Therapeutic Medicine. 2024, 27(5): 215. https://doi.org/10.3892/etm.2024.12503