The association between augmentation index and arterial stiffness index
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Objective To explore the association between arterial system augmentation index(AI) and brachial-ankle pulse wave velocity (baPWV). Methods All subjects were selected from a local community. The study included 1752 people living in Shijingshan district, Beijing during April to June,2010. Subjects whose age ranged from 23 to 90 years old [(59.82±11.88) years old] were included and 56.7% of the subjects were women. Pulse wave at the left radial artery was measured and the AI was calculated by Colin pulse wave detection device HEM9000AI. baPWV and ankle-brachial index (ABI) were measured using Colin noninvasive arteriosclerosis tester VP-1000. Color doppler flow imaging was used to measure intima-media thickness (IMT) of the bilateral carotid artery. Results The baPWV was significantly higher in ABI0.9 group and IMT0.9 mm group, while there was no significant difference of AI75 between groups. AI had a low correlation with baPWV (r = -0.068, P = 0.005). Partial correlation analysis showed that there was no significant association between AI and baPWV (r = -0.033, P = 0.17). In multiple stepwise regression analysis, the factors of AI included gender, age, BMI, waist-to-hip ratio, heart rate, ABI and systolic pressure. Conclusion No significant correlation can be found between AI and baPWV. Various factors may influence the measurement of AI. This study suggests that AI may not be a sensitive and reliable index for the evaluation of arterial stiffness.
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 Weber T, Auer J, O’rourke MF,(et al). Increased arterialwave reflections predict severe cardiovascular events in patientsundergoing percutaneous coronary interventions. ChineseJ Pract Nerv Dis, 2012, 26: 2657?2663
 Barnes JN, Nualnim N, Sugawara J, et al.Arterial stiffening,wave reflection, and inflammation in habitually exercisingsystemic lupus erythematosus patients. Am J Hypertens ,2011, 24: 1194?1200
 Hope SA, Antonis P, Adam D, et al.Arterial pulse wave velocitybut not augmentation index is associated with coronaryartery disease extent and severity: implications for arterialtransfer function applicability. J Hypertens , 2007, 25:2105?2109
 Pannier BM, Avolio AP, Hoeks A, et al.Methods and devicesfor measuring arterial compliance in humans. Am JHypertens , 2011, 15: 743?753
 Koivistoinen T, Virtanen M, Hutri -Kahonen N, et al.Arterial pulse wave velocity in relation to carotidintima-media thickness, brachial flow-mediated dilation and
carotid artery distensibility: the Cardiovascular Risk inYoung Finns Study and the Health 2000 Survey. Atherosclerosis, 2012, 220: 387?393
 Khan AA, Bhatti SN, Khan G, et al.Clinical and radiological findings in Arnold Chiari malformation. J Ayub Med Coll Abbottabad , 2010, 22: 75?78
 Yu ZM, Hong K, Bian KJ, et al.Hypertensive patients with central arterial reflex enhancement and insulin resistance index. Hainan Med J, 2011, 2: 62?64
 Mitchell GF, Parise H, Benjamin EJ, et al.Changes in arterial stiffness and wave reflection with advancing age in healthy men and women: the Framingham Heart Study. Hypertension, 2011, 43: 1239?1245