Objective To investigate the effect of 52 neurological tests on early screening of cerebral palsy in high-risk premature infants. Methods 52 Neurological examination were conducted to 363 cases of 28 to 32 weeks of high-risk preterm children at 1 month, 3 months, 6 months respectively after they were birthed from 2009 to 2012. If the children were checked with abnormal items (2 items of checked results were abnormal), they will be closely observed and urge their parents to recheck 1 month later, if the check results were still abnormal, the children would start to be early intervention treated immediately in our department; if the children were checked to have more than 3 items abnormal , he will start to be early intervention treated immediately. Meanwhile, 302 cases of heath premature children without early screening were set up as control group. All children were followed up for 36 months. With the Gesell scale to evaluate the child’s intelligence and sports development. Results 81 Cases of suspected cerebral palsy were found by this method, including 52 cases of early intervention group and 10 cases of untreated group. Another 10 cases were developed for a transient exercise. The positive rate of screening was 92.85%, and the incidence of cerebral palsy was 3.0%. After early intervention, early intervention in the preterm children group were diagnosed cerebral palsy in 5 cases to 36 months later, 17 cases of non-intervention group. Conclusion 52 Neurobehavioral examinations are a effective method for early detection of cerebral palsy in premature children, and it is helpful for early detection of cerebral palsy in premature children, early intervention, as well as to significantly reduce the incidence of cerebral palsy in premature children.