Open Access Peer-reviewed Research Article

Predictors of in-hospital mortality among patients with status epilepticus in Lubumbashi, Democratic Republic of the Congo: A retrospective study

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Submitted   Jan 3, 2024
Published   Apr 4, 2024
Issue    Vol 5 No 1 (2023)
DOI   10.25082/AGPM.2023.01.003

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Marcellin Bugeme
Faculty of Medicine, University of Lubumbashi, Lubumbashi, Democratic Republic of the Congo
Olivier Mukuku corresponding author
Institut Supérieur des Techniques Médicales de Lubumbashi, Lubumbashi, Democratic Republic of the Congo
Lucien Nawej Ditend
Faculty of Medicine, University of Lubumbashi, Lubumbashi, Democratic Republic of the Congo
Emmanuel Kiyana Muyumba
Faculty of Medicine, University of Lubumbashi, Lubumbashi, Democratic Republic of the Congo
Béatrice Koba Bora
Faculty of Medicine, University of Lubumbashi, Lubumbashi, Democratic Republic of the Congo

Abstract

Objective: Status Epilepticus (SE) is a condition characterized by an epileptic seizure that persists long enough or recurs at sufficiently short intervals to create a fixed and lasting epileptic condition. The objective of this study was to determine the prevalence and to identify predictors of in-hospital death among SE patients in Lubumbashi, Democratic Republic of the Congo (DRC).
Methods: We conducted a retrospective study from January 2020 to December 2022.
Results: Out of 3,006 patients admitted to the neurology department of the University Clinics of Lubumbashi, 97 presented with SE (i.e., a hospital prevalence of 3.23%). The mean age of the patients was 38.38±14.74 years, and men represented 77.3% of the cases. Epileptic patients represented 21.65% of the cases and 66.7% of them were on antiepileptic drugs (AEDs). Seizures were generalized in 72.16% of the patients. Seizures lasted 30 minutes or more in 50.52% of the cases. The most frequent etiologies were strokes, followed by central nervous system (CNS) infections. In-hospital mortality was 24.74% and the predictors of this mortality were CNS infections (adjusted OR = 22.34 [2.69-222.65]; p = 0.0006) and seizures lasting ≥ 30 minutes (adjusted OR = 10.98 [2.89-62.70]; p<0.0001).
Conclusion: SE is a major neurological emergency requiring early and multidisciplinary management to preserve the vital prognosis because, without treatment, SE causes important neurological complications and even death. The present study found a mortality of 24.74% which was associated with seizure duration of more than 30 minutes as well as with infectious etiologies.

Keywords
Status Epilepticus, mortality, Lubumbashi, DRC

Article Details

How to Cite
Bugeme, M., Mukuku, O., Ditend, L. N., Muyumba, E. K., & Bora, B. K. (2024). Predictors of in-hospital mortality among patients with status epilepticus in Lubumbashi, Democratic Republic of the Congo: A retrospective study. Advances in General Practice of Medicine, 5(1), 90-96. https://doi.org/10.25082/AGPM.2023.01.003
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