Open Access Peer-reviewed Research Article

Women’s breast cancer risk factors in Kinshasa, Democratic Republic of the Congo

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Multiple logistic regression
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Submitted   Apr 30, 2022
Published   Jun 15, 2022
Issue    Vol 4 (2022)
DOI   10.25082/CCR.2022.01.003

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Stanislas Maseb'a Mwang Sulu
Nganda Hospital Center of Kinshasa, Kinshasa, Democratic Republic of the Congo
Olivier Mukuku corresponding author
Higher Institute of Medical Techniques, Lubumbashi, Democratic Republic of Congo
Arnold Maseb Sul Sulu
Nganda Hospital Center of Kinshasa, Kinshasa, Democratic Republic of the Congo
François Musul Mukeng
Nganda Hospital Center of Kinshasa, Kinshasa, Democratic Republic of the Congo
Bienvenu Lebwaze Massamba
[1] Nganda Hospital Center of Kinshasa, Kinshasa, Democratic Republic of the Congo; [2] Faculty of Medicine, University of Kinshasa, Kinshasa, Democratic Republic of the Congo
Désiré Kulimba Mashinda
School of Public Health, University of Kinshasa, Kinshasa, Democratic Republic of the Congo
Stanislas Okitotsho Wembonyama
Faculty of Medicine, University of Lubumbashi, Lubumbashi, R Democratic Republic of the Congo
Vicky Lokomba
Faculty of Medicine, University of Kinshasa, Kinshasa, Democratic Republic of the Congo
Antoine Tshimpi Wola
Faculty of Medicine, University of Kinshasa, Kinshasa, Democratic Republic of the Congo

Abstract

Purpose: Breast cancer (BC) is the most common malignancy and the leading cause of cancer-related deaths among women worldwide. Risk factors for this disease are numerous and their prevalence varies according to racial and ethnic groups and geographical regions. Therefore, we sought to identify BC risk factors in the Congolese population.
Methods: A case-control study was conducted at the Nganda Hospital Center in Kinshasa, Democratic Republic of the Congo. One hundred and sixty patients with breast cancer (cases) were compared to 320 women who did not have BC (controls). STATA version 16 was used to analyze data with statistical significance considered at p < 0.05.
Results: There is a strong association between BC in Congolese women and early menarche age (adjusted odds ratio [aOR] = 2.3; 95% CI: 1.2-4.3), family history of BC (aOR = 2.5; 95% CI: 1.2-5.5), overweight (aOR = 1.8; 95% CI: 1.1-2.7), and obesity (aOR = 7.3; 95% CI: 4.0-13.4).
Conclusion: Our results indicate the presence of certain conventional risk factors. Thus, these results will be of great value in establishing adequate evidence-based awareness and preventive measures among the Congolese population.

Keywords
breast cancer, risk factors, Congolese women, Kinshasa

Article Details

How to Cite
Sulu, S. M. M., Mukuku, O., Sulu, A. M. S., Mukeng, F. M., Massamba, B. L., Mashinda, D. K., Wembonyama, S. O., Lokomba, V., & Wola, A. T. (2022). Women’s breast cancer risk factors in Kinshasa, Democratic Republic of the Congo. Current Cancer Reports, 4(1), 139-143. https://doi.org/10.25082/CCR.2022.01.003
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This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

References

  1. Sung H, Ferlay J, Siegel RL, et al. Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. Ca A Cancer Journal for Clinicians, 2021, 71(3): 209-249. https://doi.org/10.3322/caac.21660
  2. Sulu SMM, Mashinda DK, Mukuku O, et al. Epidemiology of cancers in women in Kinshasa, Democratic Republic of the Congo. Journal of Cancer Prevention & Current Research, 2022, 13(2): 51-54. https://doi.org/10.15406/jcpcr.2022.13.00487
  3. Sulu SMM, Mukuku O and Wembonyama SO. Breast Cancer in Women in the Democratic Republic of the Congo: Current State of Knowledge. Current Cancer Reports, 2022, 4(1): 128-32. https://doi.org/10.25082/CCR.2022.01.001
  4. Hadjisavvas A, Loizidou MA, Middleton N, et al. An investigation of breast cancer risk factors in Cyprus: a case control study. BMC Cancer, 2010, 10: 447. https://doi.org/10.1186/1471-2407-10-447
  5. Lodha R, Joshi A, Paul D, et al. Association between reproductive factors and breast cancer in an urban set up at central India: A case-control study. Indian Journal of Cancer, 2011, 48: 303-307. https://doi.org/10.4103/0019-509X.84928
  6. Tamimi RM, Colditz GA, Hazra A, et al. Traditional breast cancer risk factors in relation to molecular subtypes of breast cancer. Breast cancer research and treatment, 2012, 131(1): 159-167. https://doi.org/10.1007/s10549-011-1702-0
  7. Key TJ, Verkasalo PK and Banks E. Epidemiology of breast cancer. The Lancet Oncology, 2001, 2: 133-140. https://doi.org/10.1016/S1470-2045(00)00254-0
  8. McPherson K, Steel CM and Dixon JM. Breast Cancer-epidemiology risk factors and genetics. British Medical Journal, 2000, 321: 624-628. https://doi.org/10.1136/bmj.321.7261.624
  9. Colditz GA. Epidemiology and prevention of breast cancer. ancer Epidemiology Biomarkers & Prevention, 2005, 14: 768-772. https://doi.org/10.1158/1055-9965.EPI-04-0157
  10. Bhupathiraju SN, Grodstein F, Stampfer MJ, et al. Exogenous hormone use: oral contraceptives, postmenopausal hormone therapy, and health outcomes in the Nurses’Health Study. American Journal of Public Health, 2016, 106: 1631-1637. https://doi.org/10.2105/AJPH.2016.303349
  11. Mørch LS, Skovlund CW, Hannaford PC, Iversen L, Fielding S, Lidegaard Ø. Contemporary hormonal contraception and the risk of breast cancer. N Engl J Med. 2017; 377:2228-2239. https://doi.org/10.1056/NEJMoa1700732
  12. Abedalrahman SK, Ali BM, Al-Khalidy NA, et al. Risk factors of breast cancer among Iraqi women. Journal of Contempt Medicine Science, 2019, 5(3): 149-153. https://doi.org/10.22317/jcms.v5i3.609
  13. Ayoub NM, Yaghan RJ, Abdo NM, et al. Impact of obesity on clinicopathologic characteristics and disease prognosis in pre-and postmenopausal breast cancer patients: a retrospective institutional study. Journal of Obesity, 2019, 2019: 3820759. https://doi.org/10.1155/2019/3820759
  14. Meshram II, Hiwarkar PA and Kulkarni PN. Reproductive risk factors for breast cancer: a case control study. Online Journal of Health Allied Science, 2009, 8: 1-4.
  15. Pakseresht S, Ingle GK, Bahadur AK, et al. Risk factors with breast cancer among women in Delhi. Indian Journal of Cancer, 2009, 46: 132-138. https://doi.org/10.4103/0019-509X.49151
  16. Anothaisintawee T, Wiratkapun C, Lerdsitthichai P, et al. Risk Factors of Breast Cancer: A Systematic Review and Meta-Analysis. Asia Pacific Journal of Public Health, 2013, 25(5): 368-387. https://doi.org/10.1177/1010539513488795
  17. Rastogi T, Hildesheim A and Sinha R. Opportunities for cancer epidemiology in developing countries. Nature Reviews Cancer, 2004, 4(11):909-917. https://doi.org/10.1038/nrc1475
  18. Pramanick S, Chakraborty D, Bera S, et al. A Case-Control Study on Risk Factors of Breast Cancer among Women Attending a Tertiary Care Hospital in Kolkata, India. Journal of Cell Biology & Cell Metabolism, 2020, 7: 20. https://doi.org/10.24966/CBCM-1943/100020
  19. Norsa Adah B, Rusli BN, Imran AK, et al. Risk factors of breast cancer in women in Kelantan, Malaysia. Singapore Medical Journal, 2005, 46(12): 698.
  20. Wang YC, Lin CH, Huang SP, et al. Risk Factors for Female Breast Cancer: A Population Cohort Study. Cancers, 2022, 14(3): 788. https://doi.org/10.3390/cancers14030788
  21. Elkum N, Al-Tweigeri T, Ajarim D, et al. Obesity is a significant risk factor for breast cancer in Arab women. BMC cancer, 2014, 14(1): 1-10. https://doi.org/10.1186/1471-2407-14-788
  22. McTiernan A. Obesity and cancer: the risks, science, and potential management strategies. Oncology, 2005, 19(7): 871-881.
  23. Garc´ıa-Est´evez L, Cort´es J, P´erez S, et al. Obesity and breast cancer: a paradoxical and controversial relationship influenced by menopausal status. Frontiers in Oncology, 2021, 11: 705911. https://doi.org/10.3389/fonc.2021.705911
  24. Berstad P, Coates RJ, Bernstein L, et al. A Case-Control Study of Body Mass Index and Breast Cancer Risk in White and African-American Women. Cancer Epidemiology Biomarkers & Prevention, 2010, 19(6): 1532-1544. https://doi.org/10.1158/1055-9965.EPI-10-0025
  25. Harris HR, Willett WC, Terry KL, et al. Body Fat Distribution and Risk of Premenopausal Breast Cancer in the Nurses’ Health Study II. Journal of the National Cancer Institute, 2011, 103(3): 273-278. https://doi.org/10.1093/jnci/djq500
  26. Joshi A, Paul D, Lodha KM, et al. Association between reproductive factors and breast cancer in an urban set up at central India: A case-control study. Indian Journal of Cancer, 2011, 48: 303-307. https://doi.org/10.4103/0019-509X.84928
  27. Wang F, Fang Q, Ge Z, et al. Common BRCA1 and BRCA2 mutations in breast cancer families: a meta-analysis from systematic review. Molecular Biology Reports, 2012, 39(3): 2109-2118. https://doi.org/10.1007/s11033-011-0958-0
  28. Kelsey JL, Gammon MD and John EM. Reproductive factors and breast cancer. Epidemiologic Reviews, 1993, 15: 36-47. https://doi.org/10.1093/oxfordjournals.epirev.a036115
  29. Ferguson DJ and Anderson TJ. Morphological evaluation of cell turnover in relation to the menstrual cycle in the “resting” human breast. British Journal of Cancer, 1981, 44: 177-181. https://doi.org/10.1038/bjc.1981.168
  30. Pike MC, Spicer DV, Dahmoush L, et al. Estrogens, progestogens, normal breast cell proliferation, and breast cancer risk. Epidemiologic Reviews, 1993, 15: 17-35. https://doi.org/10.1093/oxfordjournals.epirev.a036102