Prof. Gian Maria Pacifici

    • G.M. PACIFICI, L. GUSTFASSON, J.SAWE and A. RANE: Metabolic interactions between morphine and various benzodiazepines. Acta Pharmacol. Toxicol. 58, 246-252 (1986).
    • G.M. PACIFICI, A. BLANCK and A. RANE: Metabolism of benzo(a)pyrene in the nuclear and microsomal fractions from rhesus monkey liver. Acta Pharmacol. Toxicol. 58, 1-4 (1986).
    • G.M. PACIFICI, E. RICHTER, G. LEHMANN, M. WIESSLER, W. ZWICKENPFLUG and L. GIULIANI: Hydroxylation of dibutylnitrosamine in the human liver and intestinal microsomal fractions. Arch. Toxicol. 58, 196-198 (1986).
    • G.M. PACIFICI, A. VIANI and G. TADDEUCCI-BRUNELLI: Serum protein binding of furosemide in newborn infants and children. Dev. Pharmacol. Ther. 10, 413-421 (1987).
    • E. SPINA, G.M. PACIFICI, C. VON BAHR and A. RANE: Characterization of desmethylimipramine 2-hydroxylation in human fetal and adult liver microsomes. Acta Pharmacol. Toxicol. 58, 277-281 (1986).
    • G.M. PACIFICI, L.C. ERIKSSON, H. GLAUMANN and A. RANE: Profile of drug metabolizing enzymes in the nuclear and microsomial fractions from rat hepatocyte nodules and normal liver. Arch. Toxicol. 62, 336-340 (1988).
    • G.M. PACIFICI, C. BENCINI and A. RANE: Acetyltransferase in humans: development and tissue distribution. Pharmacology 32, 283-291 (1986).
    • G.M. PACIFICI, L. GIULIANI and R. CALCAPRINA: Glucuronidation of 1-naphthol in nuclear and microsomal fractions of the human intestine. Pharmacology 33,103-109 (1986).
    • G.M. PACIFICI, T. TOMSON, L. BERTILSSON and A. RANE: Valpromide/carbamazepine and risk of teratogenicity. Lancet, February 16, 397-398 (1985).
    • G.M. PACIFICI, M. WARHOLM, C. GUTHENBERG, B. MANNERVIK and A. RANE: Detoxication of styrene oxide by human liver glutathione transferase. Human Toxicol. 6, 483-490 (1987).
    • G.M. PACIFICI, A. VIANI, G. TADDEUCCI-BRUNELLI, G. RIZZO, M. CARRAI and H.U. SCHULZ: Effects of development, aging, and renal and hepatic insufficiency as well as haemodialysis on the plasma concentrations of albumin and alpha-1-acid glycoprotein: implications for binding of drugs. Ther. Drug Monitor. 8, 259-263 (1986).
    • G.M. PACIFICI, M. FRANCHI, C. BENCINI and A. RANE: Valpromide inhibits human epoxide hydrolase. Br. J. Clin. Pharmacol. 22, 269-274 (1986).
    • G.M. PACIFICI, A. VIANI, H.U. SCHULZ and H.J. FRERCKS: Plasma protein binding of furomemide in elderlies. Eur. J. Clin. Pharmacol. 32, 199-202 (1987).
    • G.M. PACIFICI, H.V. GELBOIN, S.S. PARK, and A. RANE: Ontogenic development of 7-ethoxycoumarin and 7-ethoxyresorurfin O-deethylmase in rat liver microsomes and effect of monoclonal antibodies. Pharmacol. Toxicol. 61, 1O1-103 (1987).
    • G.M. PACIFICI and A. RANE: Valpromide but not sodium hydrogen divalproate inhibits epoxide hydrolase in human liver. Acta Pharmacol. Toxicol. 60, 237-239 (1987).
    • D. MARAZZITI, P. GIUSTI, A. ROTONDO, G.F. PLACIDI and G.M. PACIFICI: Imipramine receptors in human platelets: effect of age. Int. J. Clin. Pharmacol. Res. 7, 145-148 (1987).
    • G.M. PACIFICI, H.V. GELBOIN, S.S. PARK and A. RANE: 7-ethoxycoumarin and 7-ethoxyresorufin O-deethylase in human fetal and adult liver: studies with monoclonal antibodies. Pharmacol. T oxicol. 63, 26-29 (1988).
    • G.M. PACIFICI, A. VIANI, G. TADDEUCCI-BRUNELLI, G. RIZZO and M. CARRAI: Plasma protein binding of dicloxacillin in humans: effect of age and diseases. Int. J. Clin. Pharmacol. Ther. Toxicol. 25, 622-626 (1987).
    • G.M. PACIFICI, A. VIANI, G. RIZZO, M. CARRAI, G. BIANCHETTI and P.L. MORSELLI: Plasma protein binding of zolpidem: effect of age and disease. Int. J. Clin. Pharmacol. Ther. Toxicol. 26, 439-443 (1988).
    • N. PULERA’, P.L. BERNARD, M. CARRARA, C. BENCINI and G.M. PACIFICI: Muscarinic cholinergic receptors in lung of developing rats. Dev. Pharmacol. Ther. 11, 142-146 (1988).
    • G.M. PACIFICI, M. FRANCHI, C. COLIZZI, L. GIULIANI and A. RANE: Glutathione S-trasferase in humans: development and tissue distribution. Arch. Toxicol. 61, 265-269 (1988).
    • G.M. PACIFICI, L. CUOCI and G.F. PLACIDI: Placental trasfer and distribution of pinazepam and its metabolite N-desmethyldiazepam in maternal and fetal rabit. Eur. J. Drug Metab. Pharmacokinet. 14, 1-6 (1989).
    • G.M. PACIFICI, D. PENG, P. BISTOLETTI, A. MELLGREN and A. RANE: Morphine glucuronidation in human fetal liver cultures and isolated hepatocytes. In: Pharmacokinetics in Theratogenesis Vol. II (H. Nau and W.J. Scott, Eds) pp 219-224, CRC Press Inc. Roca Raton, Florida, (1987).
    • PETRUZZELLI, P. BERNARD, P. PAOLETTI, A. RANE, C. GIUNTINI and G.M. PACIFICI: Eur. J. Clin. Pharmacol. 34, 419-421 (1988).
    • D. MARAZZITI and G.M. PACIFICI: Review of imipramine binding in platelets from psychiatric patients: its relevance to the biology of the suicide. In: Current Isues of Suicidology (H.J. Moeller, A. Schmidtke, R. Welz, eds) Springer Verlag, pg 269-275 (1988).
    • G.M. PACIFICI, M. FRANCHI, C. BENCINI, F. REPETTI, N. DI LASCIO and G.B. MURARO: Tissue distribution of drug metabolizing enzymes in humans. Xenobiotica 18, 849-856 (1988).
    • D. MARAZZITI, A. ROTONDO, G.F. PLACIDI, G. PERUGI, G.B. CASSANO and G.M. PACIFICI: The binding of imipramine to platelets membranes is reduced in panic attack. Fundam. Clin. Pharmacol. 2, 69-75 (1988).
    • G.M. PACIFICI, A. VIANI, G. RIZZO, M. CARRAI, G. BIANCHETTI and P.L. MORSELLI: Plasma protein binding of zolpidem and alpidem in humans: effect of development and liver and renal insufficiency. Proocedings of the 3rd European Congress of Pharmacokinetics and Biopharmaceutics. 283-288 (1987).
    • A. WAHLSTROM, G.M. PACIFICI, B. LINDSTROM, L. HAMMAR and A. RANE: Human liver morphine UDP-glucuronyl transferase enantioselectivity and inhibition by opioid congeners and oxazepam. Br. J. Pharmacol. 94, 864-870 (1987).
    • D. MARAZZITI, A. ROTONDO, G.F. PLACIDI, G. PERUGI, G.B. CASSANO and G.M. PACIFICI: Imipramine binding in platelets from patients with panic disorder. Pharmacopsychiatry 21, 47-49 (1988).
    • G.M. PACIFICI, M. FRANCHI, C. COLIZZI, L. GIULIANI and A. RANE: Sulfotransferase in humans: Development and tissue distribution. Pharmacology 36, 411-419 (1988).
    • G.M. PACIFICI, D.J. BACK and M. L’E. ORME: Sulfation and glucuronidation of paracetamol in human liver: Assay conditions. Biochem. Pharmacol. 37, 4405-4407 (1988).
    • G.M. PACIFICI and D.J. BACK: Sulfation and glucuronidation of ethinyloestradiol in human liver. J. Steroid Biochem. 31, 345-349 (1988).
    • G.M. PACIFICI, A. TEMELLINI, L. GIULIANI, A. RANE and F. OESCH: Valpromide is a poor inhibitor of the cytosolic epoxide hydrolase. Arch. Toxicol. 63, 157-159 (1989).
    • G.M. PACIFICI, A. TEMELLINI, L. GIULIANI, A. RANE and F. OESCH: Cytosolic epoxide hydrolase in humans: distribution and development. Arch. Toxicol. 62, 254-257 (1988).
    • G.M. PACIFICI, A. VIANI, G. RIZZO, M. CARRAI, G. BIANCHETTI, J. ALLEN and P.L. MORSELLI: Plasma protein binding of alpidem: effect of development and liver or renal insufficiency. Eur. J. Clin. Pharmacol. 37, 29-32 (1989).
    • G.M. PACIFICI, A. VIANI, G. RIZZO and M. CARRAI: Plasma protein binding of ethinyloestradiol: effect of disease and drug interaction. Int. J. Clin. Pharmacol. Ther. Toxicol. 27, 362-365 (1989).
    • G.M. PACIFICI, M. FRANCHI, G. GERVASI, V. LONGO, P. Di SIMPLICIO, A. TEMELLINI and GIULIANI: Profile of drug metabolizing enzymes in the human ileum and colon. Pharmacology 38, 137-145 (1989).
    • G.M. PACIFICI, M. FRANCHI and L. GIULIANI: Sulphotransferase in small and large human intestine. Pharmacology 38, 146-150 (1989).
    • G.M. PACIFICI and A. VIANI: Bilirubin displaces furosemide from plasma protein: the effect is greater in newborn infants than adult subjects. Dev. Pharmacol. Ther. 14, 90-95 (1990).
    • G.M. PACIFICI, M. FRANCHI, L. VANNUCCI and F. MOSCA: Sulfation and glucuronidation of ethinyloestradiol in human tissues. In: Cellular and Molecular Aspects of glucuronidation (G. Siest, J. Magdalou, B. Burchell eds) John Libbey & Co Ltd. pp 321-324 (1988).
    • G.M. PACIFICI, M. FRANCHI and L. GIULIANI: Is there the cytosolic glucuronyl transferase in human liver? In: Cellular and Molecular Aspects of Glucuronidation (G. Siest, J. Magdalou, B. Burchell, Eds) John Libbey & Co Ltd. pp 93-101 (1988).
    • M. CAPPIELLO, M. FRANCHI, L. GIULIANI and G.M. PACIFICI: Distribution of sulphotransferase and its endogenous substrate: adenosine 3′-phosphate 5′-posphosulphate in human tissues. Eur. J. Clin. Pharmacol. 37, 317-32O (1989).
    • M. CAPPIELLO, M. FRANCHI, A. RANE and G.M. PACIFICI: Sulphotransferase and its substrate adenosine 3′-phosphate 5′-phosphosulphate in human fetal liver and placenta. Dev. Pharmacol. Ther. 14, 108-114 (1990).
    • A. VIANI, A. TEMELLINI, G. TUSINI and G.M. PACIFICI: Sulphotransferase and glucuronyl transferase of the human brain. Human Toxicology 9, 65-69 (1989).
    • G.M. PACIFICI, A. VIANI, M. FRANCHI, S. SANTERINI, L. GIULIANI and M. CARRAI: Conjugation pathways in liver disease. Br. J. Clin. Pharmacol. 30, 427-435 (1990).
    • G.M. PACIFICI, M. FRANCHI and A. RANE: Development of the glucuronyltransferase and sulphotransferase towards 2-naphthol in human fetus. Dev. Pharmacol. Ther. 14, 108-114 (1990).
    • A. VIANI, M. CARRAI and G.M. PACIFICI: Plasma protein binding of furosemide in liver disease: effect of hypoalbuminemia and hyperbilirubinemia. Br. J. Clin. Pharmacol. 28, 175-178 (1989).
    • V. LONGO, G.M. PACIFICI, G. PANATTONI, F. URSINO and P.G. GERVASI: Metabolism of diethylnitrosamine by microsomes of human respiratory nasal mucosa and liver. Biochem. Pharmacol. 38, 1867-1869 (1989).
    • G.M. PACIFICI, A. VIANI, P.G. GERVASI, V. LONGO, P. DI SIMPLICIO, A. TEMELLINI, P. ROMITI, S. SANTERINI, L. VANNUCCI and F. MOSCA: Profile of drug metabolizing enzymes in the cortex and medulla of the human kidney. Pharmacology 39, 299-308 (1989).
    • M. CAPPIELLO, L. GIULIANI and G.M. PACIFICI: Differential distribution of phenol- and catechol- sulphotransferases in human liver and intestine. Pharmacology 40, 69-76 (1990).
    • A. VIANI, M. CAPPIELLO, D. SILVESTRI and G.M. PACIFICI: Binding of furosemide to albumin isolated from human fetal and adult serum: similarities and differences. Dev. Pharmacol. Ther. 16, 33-40 (1991).
    • G.M. PACIFICI, S. SANTERINI, L. GIULIANI and A. RANE: Thiomethyltransferase in humans: development and tissue distribution. Dev. Pharmacol. Ther. 17, 8-15 (1991).
    • G.M. PACIFICI, P. ROMITI, L. GIULIANI and A. RANE: Thiopurinemethyltransferase in humans development and tissue distribution. Dev. Pharmacol. Ther. 17, 16-23 (1991).
    • A. TEMELLINI, M. FRANCHI, L. GIULIANI and G.M. PACIFICI: Human liver sulphotransferase and glucuronyltransferase: structure-activity relationship for phenolic substrates. Xenobiotica 21, 171-177 (1991).
    • A. TEMELLINI, L. GIULIANI and G.M. PACIFCI: Interindividual variability of glucuronidation and sulfation of ethinyloestradiol in human liver. Br. J. Clin. Pharmacol. 31, 661-664 (1991).
    • G.M. PACIFICI, L. VANNUCCI, C. BENCINI and F. MOSCA: Sulfation of hydroxy biphenyls in human tissues. Xenobiotica 9, 1113-1118 (1991).
    • G.M. PACIFICI, S. SANTERINI and L. GIULIANI: Methylation of captopril in human tissues. Xenobiotica 9, 1107-1112 (1991).
    • M. CAPPIELLO, L. GIULIANI, A. RANE and G.M. PACIFICI: Differential development of phenol and catechol sulphotransferases in human fetus. Dev. Pharmacol. Ther. 16, 83-88 (1991).
    • M. CAPPIELLO, L. GIULIANI and G.M. PACIFICI: Distribution of UDP-glucoronosyltransferase and its endogenous substrate 5′-uridine-diphospho-glucuronic acid in human. Eur. J. Clin. Pharmacol. 41, 345-350 (1991).
    • CAPPIELLO M, GIULIANI L. RANE A, and G.M. PACIFICI: Dopamine sulphotransferase is better developed than p-nitrophenol sulphotransferase in the human fetus. Dev. Pharmacol. Ther. 16, 83-88 (1991).
    • E. TESTAI, J. KEIZER, G.M. PACIFICI and L. VITOZZI: Chloroform bioactivation by microsomes from colonic and ileal mucosa of rat and man. Toxicol. Letters 57, 19-27 (1991).
    • P. ROMITI, L. GIULIANI and G.M. PACIFICI: Interindividual variability in the N-sulfation of desipramine in human liver and Platelets. Br. J. Clin. Pharmacol. 33, 17-23 (1992).
    • A. VIANI, M. CAPPIELLO and G.M. PACIFICI: Binding of diazepam, salicylic acid and digitoxin to albumin isolated from fetal and adult serum. Dev. Pharmacol. Ther. 17, 100-108 (1991).
    • G.M. PACIFICI, S. MOGAVERO, L. GIULIANI and RANE: Conjugation of benzoic acid with glycine in human fetal and adult liver and kidney. Dev. Pharmacol. Ther. 17, 52-62 (1991).
    • A. VIANI, G. RIZZO, M. CARRAI & G.M. PACIFICI: Differential effect of aging on albumin and plasma protein binding of diazepam and salicylic acid in healthy subjects and renal patients. Br. J. Clin. Pharmacol. 33, 299-304 (1991).
    • S. PETRUZZELLI, M. FRANCHI, L. GRONCHI, P. MACCHIARINI, G.M. PACIFICI and C. GIUNTINI: Cigarette smoke inhibits cytosolic but not microsomal Epoxide of human lung. Human Toxicology 11, 99-103 (1991).
    • G.M. PACIFICI and A. VIANI: Methods of determining plasma and tissue binding of drugs and pharmacokinetic consequences. Clin. Pharmacokinet. 23, 449-468 (1992).
    • G.M. PACIFICI, M. KUBRICH, L. GIULIANI, M. DE VRIES and A. RANE: Sulfation and glucuronidation of ritodrine in human fetal and adult liver. Eur. J. Clin. Pharmacol. 41, 259-264 (1991).
    • A. VIANI and G.M. PACIFICI: Quantitative contribution of the endogenous compounds and hypoalbuminaemia in reducing the binding of furosemide in the plasma of newborn infants. Dev. Pharmacol. Ther. 18, 39-43 (1992).
    • A. VIANI, G. RIZZO, M. CARRAI and G.M. PACIFICI: Interindividual variability in the concentration of albumin and alpha-1-acid glycoprotein in patients with renal or liver disease, newborns and healthy subjects: implications for binding of drugs. Int. J. Clin. Pharmacol. Ther. Toxicol. 30, 128-133 (1992).
    • G.M. PACIFICI, P. DONATELI and L. GIULIANI: Histamine N-methyltransferase: inhibition by drugs. Br. J. Clin. Pharmacol. 34, 128-133 (1992).
    • A. TEMELLINI, F. MOSCA and G.M. PACIFICI: Conjugation of benzoic acid with glycine in human liver and kidney: a study on the interindividual variability. Xenobiotica 23, 1427-1433 (1993).
    • G.M. PACIFICI, R. BIGOTTI, G. MARCHI and L. GIULIANI: Minoxidil sulfation in human liver and platelets: a study on the interindividual variability. Eur. J. Clin. Pharmacol. 45, 337-341 (1993).
    • G.M. PACIFICI AND G. MARCHI: Phenol and catechol sulphotransferases in platelets from adult subjects and newborns: a study on the interindividual variability. Br. J. Clin. Pharmacol. 36, 593-597 (1993).
    • G.M. PACIFICI, P. ROMITI, S. SANTERINI and L. GIULIANI: S-Methyltrasferases in human intestine: differential distribution of the microsomal and cytosolic forms along the human bowel. Xenobiotica 23, 671-679 (1993).
    • G.M. PACIFICI, M. BIGOTTI and L. GIULIANI: The intestine is the primary site of the in vitro sulfation of (+) and (-) terbutaline. Eur. J. Clin. Pharmacol. 45, 483-487 (1993).

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