Open Access Peer-reviewed Review

Main Article Content

Onyenmechi Johnson Afonne corresponding author
Emeka Chinedu Ifediba
Anulika Johnson Afonne

Abstract

Sleep deprivation is gradually becoming a common phenomenon in modern societies, especially among chronic users of social media, night shifts workers, students and some less-privileged populations. The erroneous perception among certain subgroups of the population that time spent to sleep is time wasted is of great concern, because sleep is indeed critical for good health and survival. Of greater concern are the effects of alcohol, beverages like caffeine, and environmental toxicants like heavy metals and pesticides, on normal sleep mechanisms. The consequences of sleep disorder are dire as it alters immune responses and have been reported to increase the risk of some non-communicable diseases. The inter-individual differences in sleep requirements may present a challenge in determining adequate sleep duration. On the average, most adults need about seven to eight hours of sleep each night while teens and children need more. Accumulation of sleep debt for individuals sleeping less than the required sleeping duration may lead to chronic health and behavioural problems. We opine that the mechanisms underlying sleep disruption by some foods and toxicants have toxicogenic link. There is need, therefore, to consider sleep deprivation as a public health issue with a view to ensuring proper advocacy among risk groups in order to improve quality of life and economy of nations. Given the prevalence of alcohol and caffeine consumption, exposures to heavy metals and pesticides, and increasing neurodegenerative disorders, there is need to elucidate the precise mechanisms of sleep disruption and exposures to the aforementioned chemicals.

Keywords
environmental toxicants, neurodegenerative diseases, public health, sleep deprivation, toxicogenic drive

Article Details

How to Cite
Afonne, O. J., Ifediba, E. C., & Afonne, A. J. (2022). Sleep deprivation: A toxicogenic drive for neurodegenerative diseases and public health issue. Advances in Health and Behavior, 5(1), 233-241. https://doi.org/10.25082/AHB.2022.01.006

References

  1. Hortsch M. A short history of the synapse-Golgi versus Ramon y Cajal. The Sticky Synapse, 2009, 1-9.
  2. Brown RE, Basheer R, McKenna JT, et al. Control of sleep and wakefulness. Physiological Reviews, 2012, 92(3): 1087-1187. https://doi.org/10.1152/physrev.00032.2011
  3. de Lecea L, Kilduff TS, Peyron C, et al. The hypocretins: hypothalamus-specific peptides with neuroexcitatory activity. Proceedings of the National Academy of Sciences of the United States of America, 1998, 95(1): 322-327. https://doi.org/10.1073/pnas.95.1.322
  4. Sakurai T, Amemiya A, Ishii M, et al. Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior. Cell, 1998, 92(4): 573-585. https://doi.org/10.1016/s0092-8674(00)80949-6
  5. Scammell TE and Winrow CJ. Orexin receptors: pharmacology and therapeutic opportunities. Annual Review of Pharmacology and Toxicology, 2011, 51: 243-266. https://doi.org/10.1146/annurev-pharmtox-010510-100528
  6. Acuna-Goycolea C, Li Y and Van Den Pol AN. Group III metabotropic glutamate receptors maintain tonic inhibition of excitatory synaptic input to hypocretin/orexin neurons. The Journal of Neuroscience, 2004, 24(12): 3013-3022. https://doi.org/10.1523/JNEUROSCI.5416-03.2004
  7. Liu ZW and Gao XB. Adenosine inhibits activity of hypocretin/orexin neurons by the A1 receptor in the lateral hypothalamus: a possible sleep-promoting effect. Journal of Neurophysiology, 2007, 97(1): 837-848. https://doi.org/10.1152/jn.00873.2006
  8. Ohno K, Hondo M and Sakurai T. Cholinergic regulation of orexin/hypocretin neurons through M(3) muscarinic receptor in mice. Journal of Pharmacological Sciences, 2008, 106(3): 485-491. https://doi.org/10.1254/jphs.fp0071986
  9. Muraki Y, Yamanaka A, Tsujino N, et al. Serotonergic regulation of the orexin/hypocretin neurons through the 5-HT1A receptor. The Journal of Neuroscience, 2004, 24(32): 7159-166. https://doi.org/10.1523/JNEUROSCI.1027-04.2004
  10. Gottesmann C. GABA mechanisms and sleep. Neuroscience, 2002, 111(2): 231-239. https://doi.org/10.1016/s0306-4522(02)00034-9
  11. Munoz M and Covenas R. Involvement of substance P and the NK-1 receptor in human pathology. Amino Acids, 2014, 46(7):1727-1750. https://doi.org/10.1007/s00726-014-1736-9
  12. Steinhoff MS, von Mentzer B, Geppetti P, et al. Tachykinins and their receptors: contributions to physiological control and the mechanisms of disease. Physiological Reviews, 2014, 94(1): 265-301.https://doi.org/10.1152/physrev.00031.2013
  13. Zielinski MR, Karpova SA, Yang X, et al. Substance P and the neurokinin-1 receptor regulate electroencephalogram non-rapid eye movement sleep slow-wave activity locally. Neuroscience, 2015, 284: 260-272. https://doi.org/10.1016/j.neuroscience.2014.08.062
  14. Zielinski MR and Krueger JM. Sleep and innate immunity. Frontiers in Bioscience (Scholar Edition), 2011, 3(2): 632-642. https://doi.org/10.2741/s176
  15. Nicoletti M, Neri G, Maccauro G, et al. Impact of neuropeptide substance P an inflammatory compound on arachidonic acid compound generation. International Journal of Immunopathology and Pharmacology, 2012, 25(4): 849-857. https://doi.org/10.1177/039463201202500403
  16. Morairty SR, Dittrich L, Pasumarthi RK, et al. A role for cortical nNOS/NK1 neurons in coupling homeostatic sleep drive to EEG slow wave activity. Proceedings of the National Academy of Sciences of the United States of America, 2013, 110(50): 20272-20277. https://doi.org/10.1073/pnas.1314762110
  17. Dittrich L, Heiss JE, Warrier DR, et al. Cortical nNOS neurons co-express the NK1 receptor and are depolarized by Substance P in multiple mammalian species. Frontiers in Neural Circuits, 2012, 6: 31. https://doi.org/10.3389/fncir.2012.00031
  18. Hirshkowitz M, Whiton K, Albert SM, et al. National Sleep Foundations’ sleep time duration recommendations: methodology and result summary. Sleep Health, 2015, 1(1): 40-43. https://doi.org/10.1016/j.sleh.2014.12.010
  19. Goel N, Rao H, Durmer JS, et al. Neurocognitive consequences of sleep deprivation. Seminars in Neurology, 2009, 29(4): 320-339. https://doi.org/10.1055/s-0029-1237117
  20. Bonnet MH and Arand DL. Hyperarousal and insomnia: state of the science. Sleep Medicine Reviews, 2010, 14(1): 9-15. https://doi.org/10.1016/j.smrv.2009.05.002
  21. Orzeł-Gryglewska J. Consequences of sleep deprivation. International Journal of Occupational Medicine and Environmental Health, 2010, 23(1): 95-114. https://doi.org/10.2478/v10001-010-0004-9
  22. Guarnieri B, Adorni F, Musicco M, et al. Prevalence of sleep disturbances in mild cognitive impairment and dementing disorders: a multicenter Italian clinical cross-sectional study on 431 patients. Dementia and Geriatric Cognitive Disorders, 2012, 33: 50-58. https://doi.org/10.1159/000335363
  23. Cordone S, Annarumma L, Rossini PM, et al. Sleep and $beta$-Amyloid deposition in Alzheimer disease: insights on mechanisms and possible innovative treatments. Frontiers in Pharmacology, 2019, 10: 695. https://doi.org/10.3389/fphar.2019.00695
  24. Yulug B, Hanoglu L and Kilic E. Does sleep disturbance affect the amyloid clearance mechanisms in Alzheimer’s disease? Psychiatry and Clinical Neurosciences, 2017, 71(10): 673-677. https://doi.org/10.1111/pcn.12539
  25. Asatryan L, Nam HW, Lee MR, et al. Implication of the purinergic system in alcohol use disorders. Alcoholism, Clinical and Experimental Research, 2011, 35(4): 584-594. https://doi.org/10.1111/j.1530-0277.2010.01379.x
  26. Nam HW, McIver SR, Hinton DJ, et al. Adenosine and glutamate signaling in neuron-glial interactions: implications in alcoholism and sleep disorders. Alcoholism, Clinical and Experimental Research, 2012, 36(7): 1117-1125. https://doi.org/10.1111/j.1530-0277.2011.01722.x
  27. Thakkar MM, Engemann SC, Sharma R, et al. Role of wake-promoting basal forebrain and adenosinergic mechanisms in sleep-promoting effects of ethanol. Alcoholism, Clinical and Experimental Research, 2010, 34(6): 997-1005. https://doi.org/10.1111/j.1530-0277.2010.01174.x
  28. Cui C, Noronha A, Warren K, et al. Brain pathways to recovery from alcohol dependence. Alcohol, 2015, 49(5): 435-452. https://doi.org/10.1016/j.alcohol.2015.04.006
  29. Sharma R, Engemann S, Sahota P, et al. Role of adenosine and wake-promoting basal forebrain in insomnia and associated sleep disruptions caused by ethanol dependence. Journal of Neurochemistry, 2010, 115(3): 782-794. https://doi.org/10.1111/j.1471-4159.2010.06980.x
  30. Colrain IM, Nicholas CL and Baker FC. Alcohol and the sleeping brain. Handbook of Clinical Neurology, 2014, 125: 415-431. https://doi.org/10.1016/B978-0-444-62619-6.00024-0
  31. Knapp CM, Ciraulo DA and Datta S. Mechanisms underlying sleep-wake disturbances in alcoholism: focus on the cholinergic pedunculopontine tegmentum. Behavioural Brain Research, 2014, 274: 291-301. https://doi.org/10.1016/j.bbr.2014.08.029
  32. Thakkar MM, Winston S and McCarley RW. A1 receptor and adenosinergic homeostatic regulation of sleep-wakefulness: effects of antisense to the A1 receptor in the cholinergic basal forebrain. Journal of Neurosciences, 2003, 23(10): 4278-4287. https://doi.org/10.1523/JNEUROSCI.23-10-04278.2003
  33. Chakravorty S, Chaudhary NS and Brower KJ. Alcohol dependence and its relationship with insomnia and other sleep disorders. Alcoholism, Clinical and Experimental Research, 2016, 40(11): 2271-2282. https://doi.org/10.1111/acer.13217
  34. Kyung Lee E and Douglass AB. Sleep in psychiatric disorders: where are we now? Canadian Journal of Psychiatry, 2010, 55(7): 403-412. https://doi.org/10.1177/070674371005500703
  35. Lydon DM, Ram N, Conroy DE, et al. The within-person association between alcohol use and sleep duration and quality in situ: an experience sampling study. Addictive Behaviors, 2016, 61: 68-73. https://doi.org/10.1016/j.addbeh.2016.05.018
  36. Crum RM, Ford DE, Storr CL, et al. Association of sleep disturbance with chronicity and remission of alcohol dependence: data from a population-based prospective study. Alcoholism, Clinical and Experimental Research, 2004, 28(10): 1533-1540. https://doi.org/10.1097/01.alc.0000141915.56236.40
  37. Thakkar MM, Sharma R and Sahota P. Alcohol disrupts sleep homeostasis. Alcohol, 2015, 49(4): 299-310. https://doi.org/10.1016/j.alcohol.2014.07.019
  38. Clark I and Landolt HP. Coffee, caffeine, and sleep: A systematic review of epidemiological studies and randomized controlled trials. Sleep Medicine Reviews, 2017, 31: 70-78. https://doi.org/10.1016/j.smrv.2016.01.006
  39. Heckman MA, Weil J and Gonzalez de Mejia E. Caffeine (1,3,7-trimethylxanthine) in foods: a comprehensive review on consumption, functionality, safety, and regulatory matters. Journal of Food Science, 2010, 75(3): 77-87. https://doi.org/10.1111/j.1750-3841.2010.01561.x
  40. Porkka-Heiskanen T. Sleep homeostasis. Current Opinion in Neurobiology, 2013, 23(5): 799-805. https://doi.org/10.1016/j.conb.2013.02.010
  41. Fredholm BB, Bättig K, Holmén J, et al. Actions of caffeine in the brain with special reference to factors that contribute to its widespread use. Pharmacological Reviews, 1999, 51(1): 83-133.
  42. Clark I and Landolt HP. Coffee, caffeine, and sleep: A systematic review of epidemiological studies and randomized controlled trials. Sleep Medicine Reviews, 2017, 31: 70-78. https://doi.org/10.1016/j.smrv.2016.01.006
  43. Landolt HP, Dijk DJ, Gaus SE, et al. Caffeine reduces low-frequency delta-activity in the human sleep EEG. Neuropsychopharmacology, 1995, 12(3): 229-238. https://doi.org/10.1016/0893-133X(94)00079-F
  44. Carrier J, Fernandez-Bolanos M, Robillard R, et al. Effects of caffeine are more marked on daytime recovery sleep than on nocturnal sleep. Neuropsychopharmacology, 2007, 32(4): 964-972. https://doi.org/10.1038/sj.npp.1301198
  45. Robillard R, Bouchard M, Cartier A, et al. Sleep is more sensitive to high doses of caffeine in the middle years of life. Journal of Psychopharmacology, 2015, 29(6): 688-697. https://doi.org/10.1177/0269881115575535
  46. Drake C, Roehrs T, Shambroom J, et al. Caffeine effects on sleep taken 0, 3, or 6 hours before going to bed. Journal of Clinical Sleep Medicine, 2013, 9(11): 1195-1200. https://doi.org/10.5664/jcsm.3170
  47. Weibel J, Lin Y-S, Landolt H-P, et al. The impact of daily caffeine intake on nighttime sleep in young adult men. Scientific Reports, 2021, 11(1): 4668. https://doi.org/10.1038/s41598-021-84088-x
  48. Kordas K, Casavantes KM, Mendoza C, et al. The association between lead and micronutrient status, and children's sleep, classroom behavior, and activity. Archives of Environmental & Occupational Health, 2007, 62(2): 105-112. https://doi.org/10.3200/AEOH.62.2.105-112
  49. Bener A, Almehdi AM, Alwash R, et al. A pilot survey of blood lead levels in various types of workers in the United Arab Emirates. Environment International, 2001, 27(4): 311-314. https://doi.org/10.1016/s0160-4120(01)00061-7
  50. Liu J, Liu X, Pak V, et al. Early blood lead levels and sleep disturbance in preadolescence. Sleep, 2015, 38(12): 1869-1874. https://doi.org/10.5665/sleep.5230
  51. Liu J and Lewis G. Environmental toxicity and poor cognitive outcomes in children and adults. Journal of Environmental Health, 2014, 76(6): 130-138.
  52. Nava-Ruiz C, Mendez-Armenta M and Rios C. Lead neurotoxicity: effects on brain nitric oxide synthase. Journal of Molecular Histology, 2012, 43(5): 553-563. https://doi.org/10.1007/s10735-012-9414-2
  53. Lidsky TI and Schneider JS. Lead neurotoxicity in children: basic mechanisms and clinical correlates. Brain, 2003, 126(Pt 1): 5-19. https://doi.org/10.1093/brain/awg014
  54. Lechin F, Pardey-Maldonado B and van der Dijs B, et al. Circulating neurotransmitters during the different wake-sleep stages in normal subjects. Psychoneuroendocrinology, 2004, 29(5): 669-685. https://doi.org/10.1016/S0306-4530(03)00095-7
  55. Bouchard M, Bellinger DC, Weuve J, et al. Blood lead levels and major depressive disorder, panic disorder, and generalized anxiety disorder in US young adults. Archives of General Psychiatry, 2009, 66(12): 1313-1319. https://doi.org/10.1001/archgenpsychiatry.2009.164
  56. Singh TD, Patial K, Vijayan VK, et al. Oxidative stress and obstructive sleep apnoea syndrome. The Indian Journal of Chest Diseases & Allied Sciences, 2009, 51(4): 217-224.
  57. Mediano O, Barceló A, de la Peña M, et al. Daytime sleepiness and polysomnographic variables in sleep apnoea patients. The European Respiratory Journal, 2007, 30(1): 110-113. https://doi.org/10.1183/09031936.00009506
  58. Liu J, Liu X, Wang W, et al. Blood lead concentrations and children’s behavioral and emotional problems: a cohort study. JAMA Pediatrics, 2014, 168(8): 737-745. https://doi.org/10.1001/jamapediatrics.2014.332
  59. Gregory AM and O’Connor TG. Sleep problems in childhood: a longitudinal study of developmental change and association with behavioral problems. Journal of the American Academy Child and Adolescent Psychiatry, 2002, 41(8): 964-971. https://doi.org/10.1097/00004583-200208000-00015
  60. Kobal AB and Grum DK. Scopoli’s work in the field of mercurialism in light of today’s knowledge: past and present perspectives. American Journal of Industrial Medicine, 2010, 53(5): 535-547. https://doi.org/10.1002/ajim.20798
  61. Falnoga I, Tusek-Znidaric M, Horvat M, et al. Mercury, selenium, and cadmium in human autopsy samples from Idrija residents and mercury mine workers. Environmental Research, 2000, 84(3): 211-218. https://doi.org/10.1006/enrs.2000.4116
  62. Arito H, Hara N and Torii S. Effect of methylmercury chloride on sleep-waking rhythms in rats. Toxicology, 1983, 28(4): 335-345. https://doi.org/10.1016/0300-483x(83)90007-0
  63. Gump BB, Gabrikova E, Bendinskas K, et al. Low-level mercury in children: associations with sleep duration and cytokines TNF-$alpha$ and IL-6. Environmental Research, 2014, 134: 228-232. https://doi.org/10.1016/j.envres.2014.07.026
  64. Aschner M, Syversen T, Souza DO, et al. Involvement of glutamate and reactive oxygen species in methylmercury neurotoxicity. Brazilian Journal of Medical and Biological Research, 2007, 40(3): 285-291. https://doi.org/10.1590/s0100-879x2007000300001
  65. Lilis R, Valciukas JA, Weber JP, et al. Effects of low-level lead and arsenic exposure on copper smelter workers. Archives of Environmental Health, 1985, 40(1): 38-47. https://doi.org/10.1080/00039896.1985.10545887
  66. Ishi K and Tamaoka A. Ten-years records of organic arsenic (diphenylarsinic acid) poisoning: epidemiology, clinical feature, metabolism, and toxicity. Brain and Nerve, 2015, 67(1): 5-18. https://doi.org/10.11477/mf.1416200081
  67. Shiue I. Urinary arsenic, pesticides, heavy metals, phthalates, polyaromatic hydrocarbons, and polyfluoroalkyl compounds are associated with sleep troubles in adults: USA NHANES, 2005-2006. Environmental Science and Pollution Research International, 2017, 24(3): 3108-3116. https://doi.org/10.1007/s11356-016-8054-6
  68. Postuma RB, Montplaisir JY, Pelletier A, et al. Environmental risk factors for REM sleep behavior disorder: a multicenter case-control study. Neurology, 2012, 79(5): 428-434. https://doi.org/10.1212/WNL.0b013e31825dd383
  69. Chaturvedi AK. Toxicological evaluation of mixtures of ten widely used pesticides. Journal of Applied Toxicology, 1993, 13(3): 183-188. https://doi.org/10.1002/jat.2550130308
  70. Xie L, Kang H, Xu Q, et al. Sleep drives metabolite clearance from the adult brain. Science, 2013, 342(6156): https://doi.org/10.1126/science.1241224
  71. Ju Y-ES, McLeland JS, Toedebusch CD, et al. Sleep quality and preclinical Alzheimer disease. JAMA Neurology, 2013, 70(5): 587-593. https://doi.org/10.1001/jamaneurol.2013.2334
  72. Ju YS, Ooms SJ, Sutphen C, et al. Slow wave sleep disruption increases cerebrospinal fluid amyloid-$beta$ levels. Brain, 2017, 140(8): 2104-2111. https://doi.org/10.1093/brain/awx148
  73. Shokri-Kojori E, Wang G-J, Wiers CE, et al. $beta$-amyloid accumulation in the human brain after one night of sleep deprivation. Proceedings of the National Academy of Sciences, 2018, 115(17): 4483-4488. https://doi.org/10.1073/pnas.1721694115
  74. Villafuerte G, Miguel-Puga A, Rodríguez EM, et al. Sleep deprivation and oxidative stress in animal models: a systematic review. Oxidative Medicine and Cell Longevity, 2015, 2015: 234952. https://doi.org/10.1155/2015/234952
  75. Trivedi MS, Holger D, Bui AT, et al. Short-term sleep deprivation leads to decreased systemic redox metabolites and altered epigenetic status. PLoS ONE, 2017, 12(7): e0181978. https://doi.org/10.1371/journal.pone.0181978
  76. Jówko E, Rózanski P and Tomczak A. Effects of a 36-h Survival training with sleep deprivation on oxidative stress and muscle damage biomarkers in young healthy men. International Journal of Environmental Research and Public Health 2018, 15(10): 2066. https://doi.org/10.3390/ijerph15102066
  77. Teixeira KRC, Dos Santos CP, de Madeiros LA, et al. Night workers have lower levels of antioxidant defenses and higher levels of oxidative stress damage when compared to day workers. Scientific Reports, 2019, 9(1): 4455. https://doi.org/10.1038/s41598-019-40989-6