Aims and Scope

ReviewerCreditsJournal of Pharmaceutical and Biopharmaceutical Research (JPBR) (ISSN:2630-533X)  is an open access, continuously published, international, refereed  journal. The aim of the journal is to provide the authors a timely and peer reviewed process for evaluation and publication of their manuscripts. All articles submitted to JPBR will undergo a rigorous double-blind peer review, and all published articles can be downloaded and read for free. JPBR will pay wide attention to the trends in related fields and insist on publishing original research work of highest quality.

JPBR publishes high quality original research work, reviews, and short communications in the following areas:
Pharmaceutical Sciences:
• Pharmaceutics
• Pharmacology and Toxicology
• Medicinal Chemistry
• Physical Pharmacy
• Pharmaceutical Analysis
• Chromatography and Hyphenated Techniques
• Pharmacognosy and Phytochemistry
• Nanotechnology for Pharmaceutical Drug Formulations
Biopharmaceutical Sciences:
• Biochemistry
• Biotechnology
• Molecular Biology
• Immunology and Microbiology

Vol 4 No 2 (2022)

Published: 2022-10-04

Abstract views: 49   PDF downloads: 11  

Page 283-295

Effect of experimental hyperglycemia on intestinal elimination and biliary excretion of ibuprofen enantiomers in hyperglycemic rats

blankpage Hawsar Othman Mohamed, Attila Almási, Pal Perjesi

Diabetic complications are mostly due to hyperglycemia. Hyperglycemia is reported to be associated with oxidative stress. It can result in changes in the activities of drug-metabolizing enzymes and membrane-integrated transporters, which can modify the fate of drugs and other xenobiotics. An in vivo intestinal perfusion model was used to investigate how experimental hyperglycemia affects intestinal elimination and biliary excretion of ibuprofen enantiomers in the rat. Experimental diabetes was induced by intravenous (i.v.) administration of streptozotocin. The intestinal perfusion medium contained 250 µM racemic ibuprofen. A validated isocratic chiral HPLC method with UV detection was developed to determine the amount of the two enantiomers in the intestinal perfusate and the bile. The results indicated that experimental diabetes doesn’t cause a statistically significant difference in the disappearance of ibuprofen enantiomers from the small intestine. Analysis of the bile samples detected only the (S)-IBP enantiomer. Excretion of the ibuprofen enantiomer to the bile decreased in experimental diabetes. The observed changes can affect the pharmacokinetics of drugs administered in hyperglycemic individuals.

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Prof. Pal Perjesi-photo  ISSN: 2630-533X
 Abbreviation: J Pharm Biopharm Res
 Editor-in-Chief: Prof. Pal Perjesi (Hungary)
 Publishing Frequency: Continuous publication
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 Publishing Model:
Open Access