Aims and Scope

ReviewerCreditsJournal of Pharmaceutical and Biopharmaceutical Research (JPBR) (ISSN:2630-533X)  is an open access, continuously published, international, refereed  journal. The aim of the journal is to provide the authors a timely and peer reviewed process for evaluation and publication of their manuscripts. All articles submitted to JPBR will undergo a rigorous double-blind peer review, and all published articles can be downloaded and read for free. JPBR will pay wide attention to the trends in related fields and insist on publishing original research work of highest quality.

JPBR publishes high quality original research work, reviews, and short communications in the following areas:
Pharmaceutical Sciences:
• Pharmaceutics
• Pharmacology and Toxicology
• Medicinal Chemistry
• Physical Pharmacy
• Pharmaceutical Analysis
• Chromatography and Hyphenated Techniques
• Pharmacognosy and Phytochemistry
• Nanotechnology for Pharmaceutical Drug Formulations
Biopharmaceutical Sciences:
• Biochemistry
• Biotechnology
• Molecular Biology
• Immunology and Microbiology

2024-01-16

Call for papers for the special issue: Beta coronaviruses

The Special Issue wish to cover the widest range of research with the different beta coronaviruses, focusing on the SARS-CoV-2. To encourage researchers both from the academia and the industry, the journal offers 100% waiver for those authors who submit their manuscript before May 31, 2024. We wish to ask researchers who know the field and are active practitioners of any field segment to participate.

Vol 5 No 2 (2023)

Published: 2024-05-15

Abstract views: 276   PDF downloads: 90  
2024-05-31

Page 424-429

Anticonvulsant activities of the methanol crude extract and fractions of the leaf Solanum americanum (S.a.) in pentylenetetrazole and 4-amino pyridine induced seizure in white albino rats

blankpage Rita Nwabiani, Adaora S. Ogbuagu, Isaac O. Okerulu

This research investigated the anticonvulsant effect of the crude extract and fractions of Solanum americanum’s (S.a.) leaves on seizures induced by pentylenetetrazole (PTZ) and 4- amino pyridinein albino rats to authenticate the use of the leaves in the treatment of epilepsy in South -Eastern Nigeria. The leaves of S.a were extracted with methanol and fractionated using n-hexane, ethyl acetate and methanol. The parameters observed were onset of convulsions in minutes, duration of clonic phase in minutes, percentage protection from seizures and mortality. The anticonvulsant tests were carried out using 60 (sixty) white albino rats (weighing 80-136 g) of both sexes, varying concentrations of both methanol extracts and fractions (12.5, 25.0, 50.0, 100 and 200 mg/kg b.w.) were administered to the rats after which convulsion were induced in the rats using 9.0 mg/kg of PTZ and 1.5 mg/kg 4-amino pyridine on different groups (35 and 25) of rats respectively. The results of the various groups were compared with the control group and significance was analyzed by one-way ANOVA. The acute toxicity test was conducted at a dose of 3000 mg/kg. At a peak dose of 200 mg/kg methanol crude extract, hexane and methanol fraction in PTZ model protected the animals from seizure at 89.30%, 100%, 100% but gave 80%, 80% and 60% protection from mortality respectively. Hexane fraction (12.5, 25, 50, 100 and 200 mg/kg) protected the rats against mortality at 20%, 40%, 60%, 60% and 80% respectively, while no anticonvulsant activities were detected in ethyl acetate fraction. Differences among the means and standard deviation was statistically significant at P < 0.05.The acute toxicity test showed that the leaf of S.a. is non-toxic. The result obtained substantiated the use of the leaf of Solanum americanum ethnobotanically as anticonvulsant.

Abstract views: 331   PDF downloads: 93  
2024-05-15

Page 412-416

Determination of pesticide residues and heavy metals in Adhatoda Vasaka Linn.

blankpage Ritu Tiwari, Aishwarya Chauhan, Madhavi Patel, Komal Patel

Heavy metals and pesticide residue analysis plays an important role in the quality control of medicinal plants like Vasaka (Adhatoda vasica). Hence a study was conducted to determine heavy metals and pesticide residues in this medicinal herb, which is a highly useful commodity in the health system. The reliable, rapid and nontoxic sample preparation method like QuEChERS and analytical methods like GC-MS were proposed for the simultaneous determination of pesticide residues and Heavy metal detection was carried out by ICP-MS. In this study, the presence of organophosphorus and organochlorine pesticides like alachlor, heptachlor, heptachlor epoxide, aldrin, dieldrin, endrin, etc was checked but not detected. Heavy metals like Arsenic (As), Cadmium (Cd), Mercury (Hg) and Lead (Pb) are traced in samples about 2.3005 ppb, 0.799 ppb, 2.290 ppb and 10.204 ppb respectively in the present study.

Abstract views: 314   PDF downloads: 82  
2024-06-18

Page 430-443

Blockchain technology for advanced therapy medicinal products: Applications in tracking, data sharing, and supply chain automation

blankpage Cristobal Aguilar-Gallardo, Ana Bonora-Centelles

Advanced therapy medicinal products (ATMPs) like cell and gene therapies offer transformative treatment options for many diseases. However, coordinating the decentralized, patient-specific manufacturing of autologous ATMPs across multiple hospitals poses major supply chain challenges. This paper provides a comprehensive analysis of how blockchain technology can enhance decentralized ATMP manufacturing networks. First, background on ATMPs and complexities of decentralized production is reviewed. An overview of blockchain architecture, key attributes, and existing use cases then follows. The major opportunities for blockchain integration in ATMP manufacturing are discussed in depth, including tracking autologous products across locations, enabling data sharing between hospitals to power AI-based optimization, automating supply chain processes, and maintaining provenance records. Critical limitations around scalability, privacy, regulation, and adoption barriers are examined. Design considerations for developing blockchain ecosystems tailored to the unique ATMP environment are also explored. Blockchain shows immense promise for transforming visibility, coordination, automation, and data unification in decentralized ATMP manufacturing networks. Despite current challenges, blockchain is prepared to profoundly impact the advancement of personalized cell and gene therapies through enhanced supply chain instrumentation. This paper provides a comprehensive analysis of this emerging technological innovation and its applications to address critical needs in ATMP translation and manufacturing.

Abstract views: 430   PDF downloads: 94  
2024-05-22

Page 417-423

A big threat : Aflatoxin

blankpage Ritu Tiwari, Aanal Pandaya, Poornima Gulati, Aishwarya Chahuan

The past decade has witnessed a tremendous surge of interest in herbal medicines throughout the world. Aflatoxins are naturally occurring mycotoxins that are mainly produced by Aspargillus flavus and Aspargillus parasiticus and primarily contaminate food crops such as corn, groundnuts, and tree nuts as well as herbal medicinal plants in tropical and subtropical regions of the world. It is a lethal substance that intensely or at slower ingestion influences the strength of humans and animals. Aflatoxin study is vital for a safety perspective as they are extremely lethal and cancer-causing; to overcome the health effect of aflatoxins and for better assessment and standardization of herbal plant drugs.  The investigation includes worldwide regulations on aflatoxins with their acceptable ranges in commodities. With more controls for adequate dimensions of aflatoxins set up, present-day analytical techniques have turned out to be very modern, capable of accomplishing results with high accuracy and precision, appropriate for administrative research centers and post-reap sample testing in developed countries.

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Prof. Pal Perjesi-photo  ISSN: 2630-533X
 Abbreviation: J Pharm Biopharm Res
 Editor-in-Chief: Prof. Pal Perjesi (Hungary)
 Publishing Frequency: Continuous publication
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 Publishing Model:
Open Access