Current Cancer Reports (CCR) (ISSN: 2661-3166) is an open access, peer reviewed, scholarly journal dedicated to publish articles covering all areas of carcinogenesis, prevention, diagnosis, treatment and drug development.

The journal aims at promoting research communications, and providing a platform for doctors, researchers, physicians, pharmacists and healthcare professionals to find the most recent advances in all areas of cancer-related fields. Current Cancer Reports accepts original research articles, reviews, minireviews, case reports, image data, novel hypothesis and rapid communication covering all respects of carcinogenesis and cancer therapy.

The columns of the journal include, but not limited to:
--Original articles and new techniques in cancer research and therapy
--Quick reports
--Case reports
--Clinicopathologic discussion
--Discussion of clinical case
--Expert views
--Exchange of experience
--Novel hypothesis
--Publish the original incoming letter
--Academic contending/Debate

Vol 3 No 1 (2021)

Published: 2021-06-15

Abstract views: 282   PDF downloads: 80  

Page 101-109

Problems in living among breast cancer survivors

blankpage Steven S. Coughlin, Deepak Nag Ayyala, Jorge E. Cortes

Purpose: Breast cancer survivors may experience worse social, physical, and emotional function compared to the general population, although symptoms often improve over time. Data on problems in living can help to improve interventions and supportive care for breast cancer survivors. Symptoms such as fatigue, pain, difficulties with sleep, and sexual problems may have an adverse effect on the quality of life of breast cancer survivors. Methods: We examined problems in living using data from a survey of 164 breast cancer survivors who had completed primary therapy for the disease. Results: A total of 164 women completed the study questions (response rate 16.4%). The mean age of the women was 67 years. Among all participants, 66.7% were white, 29.5% were African-American, and the remainder were of other races. Almost all of the symptoms were more likely to be reported by participants who were < 55 years of age. Other important correlates of symptoms included non-white race, marital status, and having a household income of less than $50,000 per year. Conclusion: The results of this study highlight the need for caregivers to emphasize screening for and discussion of symptoms, including sleep difficulties, fatigue, loss of strength, aches and pains, and muscle or joint stiffness. Of particular concern are younger survivors and those who are African American or low-income.

Abstract views: 410   PDF downloads: 69  

Page 95-100

Individual prostate cancer screening: Practice survey with general practitioner of Lubumbashi, Democratic Republic of Congo

blankpage Pitchou Mukaz Mbey, Dieudonné Moliwa Moningo, Augustin Mukakala Kibonge, Patrick Zihalirwa Ciza, Igor Mujinga Wa Mujinga, Manix Banza Ilunga, Gabriel Waratch Unen Wakunga, Olivier Mukuku, Willy Kalau Arung

Objective: To analyze the practices of general practitioners (GPs) in terms of recommendations on individual screening for prostate cancer (PCa). Methods: An anonymous cross-sectional survey using a pre-established questionnaire was conducted among 193 GPs in the city of Lubumbashi from May 1st to July 31st, 2020. The questionnaire included three parts: identity criteria of GPs, screening practice and the opinion of GPs on the recommendations. Results: The participation rate was 79%. Eighty-two-point nine percent of respondents said they offered screening for PCa; 42.5% of them said they offered this screening to all men within a certain age limit, ranging between 50 to 75 years in 38.8% of the cases. Only 12.5% of GPs provided complete prior information to their patients. Thirty-six-point three percent of GPs reported combining digital rectal examination with total PSA testing, but in the presence of an abnormality, 60.6% reported that they referred their patients directly to the urologist without ordering other additional investigations (first or second line). Finally, 32.7% of GPs found that the recommendations disseminated were appropriate for their practice. Conclusion: Individual screening for PCa is widely proposed; but there are differences between the practices reported by GPs and official recommendations of learned societies. Our study highlights the need to popularize the recommendations of learned societies to GPs.

Abstract views: 310   PDF downloads: 90  

Page 81-94

Predictors of prostate cancer screening among African American men treated at an Academic Medical Center in the Southern United States

blankpage Steven S. Coughlin, Deepak Nag Ayyala, John S. Luque, Justin Xavier Moore

Background: The controversy surrounding prostate cancer screening, coupled with the high rates of incidence and mortality among African American men, increase the importance of African American men engaging in an informed decision-making process around prostate cancer screening. Purpose: To examine predictors of prostate cancer screening via the prostatespecific antigen (PSA) test. Secondary objectives were to examine whether African American men have been screened for prostate cancer; their confidence in making an informed choice about whether PSA testing is right for them; and whether they have talked with their provider about PSA testing and engaged in an informed decision-making process around prostate cancer screening. Methods: We conducted a study among a sample of African American men patients ages > 40 years. Results: A total of 65 men completed the questionnaire (response rate = 6.5%). The mean age of the men was 64.4 years. Most of the participants (90.8%) reported a regular healthcare provider and that their provider had discussed the PSA test with them (81.3%). About 84.1% of the men ever had a PSA test, but only 38.0% had one in the past year. Most of the men reported that they make the final decision about whether to have a PSA test on their own (36.5%) or after seriously considering their doctor’s opinion (28.6%). About 31.8% of the men reported that they share responsibility about whether to have a PSA test with their doctor. About half of the participants (49.2%) reported that they have made a decision about whether to have a PSA test and they are not likely to change their mind. The majority of the men (75%) perceived their risk of prostate cancer to be about the same level of risk as other men who were their age. The men’s knowledge of prostate cancer was fair to good (mean prostate cancer knowledge scale = 10.37, SD 1.87). Knowledge of prostate cancer was positively associated with receipt of a PSA test (p < 0.0206). Conclusion: The modest overall prostate cancer knowledge among these participants, including their risk for prostate cancer, indicates a need for prostate cancer educational interventions in this patient population.

Abstract views: 500   PDF downloads: 99  

Page 68-80

DNA bioelectric field: a futuristic bioelectric marker of cancer, aging and death - A working hypothesis

blankpage Matti Pitkänen, Reza Rastmanesh

Telomeres are associated with the ends of DNA double strands. The lengths of the telomeres are controlled by the telomerase enzyme. The shortening of the telomeres is known to relate to aging. In cancers, telomere lengths are abnormally short. Telomeres could act as buffers shielding the part of DNA coding for the proteins. For cancer cells, germ cells and stem cells the length of the telomeres is not varying. There is an analogy with microtubules, which are highly dynamical and carry a longitudinal electric field, whose strength correlates with the microtubule length. Could sticky ends generate a longitudinal field along DNA double strand with strength determined by the lengths of the sticky ends? In the standard picture the flux of the longitudinal electric field would be proportional to the difference of the negative charges associated with the sticky ends. In TGD framework, DNA strands are accompanied by the dark analog of DNA with codons realized as 3-proton units at magnetic flux tubes parallel to DNA strands and neutralizing the negative charge of ordinary DNA except at the sticky ends. This allows considering the possibility that opposite sticky ends carry opposite charges generating a longitudinal electric field along the magnetic flux tube associated with the system. DNA/Telomere bioelectric field could serve as a novel bioelectric marker to be used for prognostic and diagnostic purposes in researches of cancer, aging, surgery grafts and rejuvenation. We propsed that DNA bioelectric field can be used as a futuristic bioelectric marker of cancer, aging and death.

Abstract views: 753   PDF downloads: 223  

Page 64-67

Hematogone hyperplasia - A double edged sword

blankpage Aditi Kundoo, Sabina Langer, Divij Sachdeva, Anupam Sachdeva, Jyoti Kotwal

Hematogone hyperplasia is seen in many reactive and neoplastic conditions such as autoimmune cytopenia(s), post viral infections, Hodgkin/ Non Hodgkin lymphoma, acute myeloid leukaemia, post chemotherapy or stem cell transplant bone marrow. However, occasionally a marked reactive process like hematogone hyperplasia can mask an important underlying morphology. It is further compounded in cases where the diagnostic cells are few in number. Clinching a diagnosis in such cases becomes increasingly difficult.

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Yuesuo Yang-photo  ISSN: 2661-3166
 Editor-in-Chief: Prof. Yingyu Cui
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