Vol 6 No 1 (2025)

The quest for novel bioactive heterocyclic frameworks continues to be a focal point in modern organic and medicinal chemistry. In this context, haloindole carboxaldehydes have emerged as valuable and versatile synthetic intermediates due to their electron-rich indole core, electrophilic aldehyde function, and tunable halogen substituents. This study presents a comprehensive synthetic and spectroscopic investigation of haloindole carboxaldehydes, aiming to harness their reactivity for the rational design and construction of structurally diverse heterocyclic compounds with potential pharmacological relevance. A series of halogenated indole-3-carboxaldehyde derivatives were synthesized via regioselective halogenation, followed by formylation under Vilsmeier–Haack conditions. Their structures were elucidated and confirmed through extensive spectroscopic characterization, including ¹H NMR, ¹³C NMR, FT-IR, UV–Vis, and mass spectrometry. Furthermore, the influence of different halogen atoms (Cl, Br, I) on the reactivity and electronic behavior of the aldehydes was systematically evaluated using electron spin resonance (ESR) and high-performance liquid chromatography (HPLC) analyses. The synthetic utility of these haloindole aldehydes was further demonstrated through their condensation with active methylene and amino compounds, facilitating the formation of fused heterocyclic systems such as β-carbolines, indolylpyrazoles, and oxazoles. Preliminary in silico screening of the resulting scaffolds revealed promising drug-likeness profiles and potential interactions with biological targets, highlighting their value in drug discovery. This work underscores the significance of haloindole carboxaldehydes as multifunctional building blocks for the development of complex molecular architectures with potential applications in therapeutic chemistry.

Present investigation analyzes various water quality parameters after TiO₂ assisted photocatalytic degradation of Giemsa Dye in aqueous suspension. Significant changes were noted in alkalinity, turbidity, hardness, nitrate, calcium ion concentration, chloride ion concentration, magnesium ion concentration, COD, BOD, sulfate ion concentration, temperature and pH. At pH 2 investigated parameters were found within the WHO standards of drinking water. Environmental risk assessment reveals that beside photocatalytic treatment, waste disposal methodology still needs to be accompanied with secondary treatment of water.