Currently, (2019-2020) COVID-19 global pandemic is caused by a member of the Coronaviridae group. Some human viruses are spread from human to human by way of droplets or aerosols, but fewer viruses are persistently airborne in transmission, and the healthcare-associated epidemic of airborne viral infection are restricted to very few surrogates. The prevention of air pollutants (i.e., biological, particles, chemicals, and smoke) at the resource has the highest efficiency to keep safe air. In addition, it is one of the most efficient tools (i.e. the second one) for preventing inside air pollution through ventilation. To our aim was to perform a rapid literature review to answer the following question: does ventilation in healthcare facilities prevention of infection COVID-19? We systematically searched Embase, PubMed/MEDLINE, Scopus, PubMed Central (PMC), Google Scholar databases as well as medRxiv by using the following key-words: ‘COVID-19’, ‘healthcare settings’, ‘prevention’, ‘ventilation’, ‘Hospital, ‘Infection’, and ‘Air changes per hour. A total of 26 eligible articles were identified. The literature denotes that temperature, relative humidity, and ventilation and air conditioning systems have beneficial effects to prevent COVID-19 infection. Thus, based on recommendations of CDC, WHO, and other studies effective ventilation is the most important transmission of respiratory disease control strategy, specially COVID-19.