Open Access Peer-reviewed Research Article

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Lisha Wu
Shiqiang Yan corresponding author
Yinta Li


To develop a new method for the synthesis of bicyclic ortho-aminocarbonitrile derivatives. Reaction of aromatic aldehydes, cycloketones and malononitrile with catalytic amount of 3-(dimethylamino)- 1-propylamine (DMAPA) in ethanol via Knoevenagel-Michael cascades. The bicyclic ortho-aminocarbonitrile derivatives were obtained with good to excellent yields along with short reaction times. The universality, excellent yields, mild reaction and easy collection through simple filtration indicate the preparation of orthoaminocarbonitriles derivatives is an efficient and suitable protocol, which use one-pot multicomponent reaction of aromatic aldehyde, cycloketone, and 2 equiv. of malononitrile under the catalytic amount of DMAPA in ethanol.

ortho-Aminocarbonitriles, DMAPA, tandem reaction, one-pot

Article Details

How to Cite
Wu, L., Yan, S., & Li, Y. (2020). Tandem reaction for the synthesis of bicyclic ortho-aminocarbonitrile derivatives using DMAPA as a cheap and efficient catalyst. Journal of Pharmaceutical and Biopharmaceutical Research, 2(2), 145-152.


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